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Kim B, Lee JY, Lee HY, et al. Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin. Biomol Ther (Seoul). 2013;21(5):343-8doi: 10.4062/biomolther.2013.032.
Kim, B., Lee, J. Y., Lee, H. Y., Nam, K. Y., Park, J., Lee, S. M., Kim, J. E., Lee, J. D., & Hwang, J. S. (2013). Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin. Biomolecules & therapeutics, 21(5), 343-8. https://doi.org/10.4062/biomolther.2013.032
Kim, Bora, et al. "Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin." Biomolecules & therapeutics vol. 21,5 (2013): 343-8. doi: https://doi.org/10.4062/biomolther.2013.032
Kim B, Lee JY, Lee HY, Nam KY, Park J, Lee SM, Kim JE, Lee JD, Hwang JS. Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin. Biomol Ther (Seoul). 2013 Sep 30;21(5):343-8. doi: 10.4062/biomolther.2013.032. PMID: 24244821; PMCID: PMC3825197.
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Biomol Ther (Seoul). 2013 Sep 30;21(5):343-8. doi: 10.4062/biomolther.2013.032.

Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin.

Biomolecules & therapeutics

Bora Kim, Jee-Young Lee, Ha-Yeon Lee, Ky-Youb Nam, Jongil Park, Su Min Lee, Jin Eun Kim, Joo Dong Lee, Jae Sung Hwang

Affiliations

  1. Enprani Co., Ltd. R&D Center of Skin Science and Cosmetics, Incheon 400-103.

PMID: 24244821 PMCID: PMC3825197 DOI: 10.4062/biomolther.2013.032

Abstract

We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with α-melanocyte stimulating hormone (α-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.

Keywords: Hesperidin; Melanophilin; Melanosome transport; Pigmented reconstructed epidermis model; Rab27A

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