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Rodríguez-Pérez AS, López-Rodríguez JF, Calvo-Turrubiartes MZ, et al. Partial baroreceptor dysfunction and low plasma nitric oxide bioavailability as determinants of salt-sensitive hypertension: a reverse translational rat study. Braz J Med Biol Res. 2013;46(10):868-880doi: 10.1590/1414-431X20132834.
Rodríguez-Pérez, A. S., López-Rodríguez, J. F., Calvo-Turrubiartes, M. Z., Saavedra-Alanís, V. M., Llamazares-Azuara, L., & Rodríguez-Martínez, M. (2013). Partial baroreceptor dysfunction and low plasma nitric oxide bioavailability as determinants of salt-sensitive hypertension: a reverse translational rat study. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 46(10), 868-880. https://doi.org/10.1590/1414-431X20132834
Rodríguez-Pérez, A S, et al. "Partial baroreceptor dysfunction and low plasma nitric oxide bioavailability as determinants of salt-sensitive hypertension: a reverse translational rat study." Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas vol. 46,10 (2013): 868-880. doi: https://doi.org/10.1590/1414-431X20132834
Rodríguez-Pérez AS, López-Rodríguez JF, Calvo-Turrubiartes MZ, Saavedra-Alanís VM, Llamazares-Azuara L, Rodríguez-Martínez M. Partial baroreceptor dysfunction and low plasma nitric oxide bioavailability as determinants of salt-sensitive hypertension: a reverse translational rat study. Braz J Med Biol Res. 2013 Oct;46(10):868-880. doi: 10.1590/1414-431X20132834. Epub 2013 Oct 12. PMID: 24141614; PMCID: PMC3854306.
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Braz J Med Biol Res. 2013 Oct;46(10):868-880. doi: 10.1590/1414-431X20132834. Epub 2013 Oct 12.

Partial baroreceptor dysfunction and low plasma nitric oxide bioavailability as determinants of salt-sensitive hypertension: a reverse translational rat study.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

A S Rodríguez-Pérez, J F López-Rodríguez, M Z Calvo-Turrubiartes, V M Saavedra-Alanís, L Llamazares-Azuara, M Rodríguez-Martínez

Affiliations

  1. Integrative Physiology Laboratory, Department of Physiology and Biophysics, San Luis Potosí, Mexico.

PMID: 24141614 PMCID: PMC3854306 DOI: 10.1590/1414-431X20132834

Abstract

This study determined whether clinical salt-sensitive hypertension (cSSHT) results from the interaction between partial arterial baroreceptor impairment and a high-sodium (HNa) diet. In three series (S-I, S-II, S-III), mean arterial pressure (MAP) of conscious male Wistar ChR003 rats was measured once before (pdMAP) and twice after either sham (SHM) or bilateral aortic denervation (AD), following 7 days on a low-sodium (LNa) diet (LNaMAP) and then 21 days on a HNa diet (HNaMAP). The roles of plasma nitric oxide bioavailability (pNOB), renal medullary superoxide anion production (RMSAP), and mRNA expression of NAD(P)H oxidase and superoxide dismutase were also assessed. In SHM (n=11) and AD (n=15) groups of S-I, LNaMAP-pdMAP was 10.5±2.1 vs 23±2.1 mmHg (P<0.001), and the salt-sensitivity index (SSi; HNaMAP-LNaMAP) was 6.0±1.9 vs 12.7±1.9 mmHg (P=0.03), respectively. In the SHM group, all rats were normotensive, and 36% were salt sensitive (SSi≥10 mmHg), whereas in the AD group ∼50% showed cSSHT. A 45% reduction in pNOB (P≤0.004) was observed in both groups in dietary transit. RMSAP increased in the AD group on both diets but more so on the HNa diet (S-II, P<0.03) than on the LNa diet (S-III, P<0.04). MAP modeling in rats without a renal hypertensive genotype indicated that the AD*HNa diet interaction (P=0.008) increases the likelihood of developing cSSHT. Translationally, these findings help to explain why subjects with clinical salt-sensitive normotension may transition to cSSHT.

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