Display options
Cite
Ricke J, Seidensticker M, Mohnike K. Noninvasive diagnosis of hepatocellular carcinoma in cirrhotic liver: current guidelines and future prospects for radiological imaging. Liver Cancer. 2012;1(1):51-8doi: 10.1159/000339020.
Ricke, J., Seidensticker, M., & Mohnike, K. (2012). Noninvasive diagnosis of hepatocellular carcinoma in cirrhotic liver: current guidelines and future prospects for radiological imaging. Liver cancer, 1(1), 51-8. https://doi.org/10.1159/000339020
Ricke, Jens, et al. "Noninvasive diagnosis of hepatocellular carcinoma in cirrhotic liver: current guidelines and future prospects for radiological imaging." Liver cancer vol. 1,1 (2012): 51-8. doi: https://doi.org/10.1159/000339020
Ricke J, Seidensticker M, Mohnike K. Noninvasive diagnosis of hepatocellular carcinoma in cirrhotic liver: current guidelines and future prospects for radiological imaging. Liver Cancer. 2012 Jun;1(1):51-8. doi: 10.1159/000339020. PMID: 24159571; PMCID: PMC3747541.
Copy Download .nbib Format: NLM
Share it on

Liver Cancer. 2012 Jun;1(1):51-8. doi: 10.1159/000339020.

Noninvasive diagnosis of hepatocellular carcinoma in cirrhotic liver: current guidelines and future prospects for radiological imaging.

Liver cancer

Jens Ricke, Max Seidensticker, Konrad Mohnike

Affiliations

  1. Klinik für Radiologie und Nuklearmedizin, Universitätsklinikum Magdeburg AÖR, Magdeburg, Germany.

PMID: 24159571 PMCID: PMC3747541 DOI: 10.1159/000339020

Abstract

Noninvasive imaging has become the standard for hepatocellular carcinoma (HCC) diagnosis in cirrhotic patients. Typical imaging features of HCC such as arterial wash-in and venous wash-out deliver very high specificity and acceptable sensitivity even in nodules from 1 to 2 cm in diameter. However, limitations apply specifically in hypovascular HCC, for which the addition of new techniques such as diffusion-weighted magnetic resonance imaging (DW-MRI) or hepatobiliary MRI is helpful. Whereas DW-MRI adds to both the sensitivity and specificity, hepatobiliary MRI additionally contributes valuable information in cirrhotic patients on the histopathology of small lesions, including early HCC and high-grade dysplastic nodules. Biopsy of small, atypical lesions is associated with a high rate of false-negative findings and should be used only after careful consideration in selected patients. Here, we review the current international guidelines on HCC diagnosis as well as the latest developments in imaging that may contribute to safe detection and accurate characterization of suspicious nodules in patients with liver cirrhosis.

Keywords: Diagnostic guidelines; HCC; Imaging; Liver; Liver cancer

References

  1. Eur Radiol. 2007 Nov;17(11):2969-82 - PubMed
  2. Hepatol Int. 2010 Mar 18;4(2):439-74 - PubMed
  3. Ann Surg Oncol. 2008 Apr;15(4):972-8 - PubMed
  4. Eur J Radiol. 2012 Nov;81(11):2973-7 - PubMed
  5. Korean J Radiol. 2011 Jul-Aug;12(4):403-15 - PubMed
  6. Am J Gastroenterol. 2007 Nov;102(11):2448-57; quiz 2458 - PubMed
  7. Hepatol Res. 2003 Jun;26(2):142-147 - PubMed
  8. Semin Liver Dis. 2010 Feb;30(1):17-25 - PubMed
  9. Hepatology. 2009 Sep;50(3):791-8 - PubMed
  10. J Cancer Res Clin Oncol. 2011 Apr;137(4):567-75 - PubMed
  11. World J Surg. 2004 Apr;28(4):376-81 - PubMed
  12. Hepatology. 2011 Mar;53(3):1020-2 - PubMed
  13. J Hepatol. 2001 Apr;34(4):570-5 - PubMed
  14. Oncology. 2010 Jul;78 Suppl 1:31-5 - PubMed
  15. Dig Dis. 2011;29(3):339-64 - PubMed
  16. AJR Am J Roentgenol. 2011 Jul;197(1):W44-52 - PubMed
  17. AJR Am J Roentgenol. 2011 Jul;197(1):58-63 - PubMed
  18. J Magn Reson Imaging. 2011 Mar;33(3):625-32 - PubMed
  19. Radiology. 2010 Sep;256(3):817-26 - PubMed
  20. Hepatology. 2011 Dec;54(6):2048-54 - PubMed
  21. Hepatol Res. 2007 Sep;37 Suppl 2:S135-8 - PubMed
  22. Eur Radiol. 2011 Apr;21(4):832-40 - PubMed
  23. J Gastroenterol. 2009;44 Suppl 19:112-8 - PubMed
  24. Hepatology. 2008 Jan;47(1):97-104 - PubMed
  25. J Gastroenterol. 2009;44(7):793-8 - PubMed
  26. Eur Radiol. 2010 Nov;20(11):2699-706 - PubMed
  27. Hepatology. 2010 Jun;51(6):2020-9 - PubMed
  28. Hepatology. 2005 Jul;42(1):27-34 - PubMed
  29. Gut. 2008 Nov;57(11):1592-6 - PubMed
  30. J Hepatol. 2012 Jun;56(6):1317-23 - PubMed
  31. Am J Gastroenterol. 2010 Mar;105(3):599-609 - PubMed
  32. Cancer Treat Rev. 2007 Aug;33(5):437-47 - PubMed
  33. Liver Transpl. 2007 Nov;13(11):1603 - PubMed
  34. Liver Transpl. 2012 Jul;18(7):850-7 - PubMed
  35. Radiology. 2005 Feb;234(2):468-78 - PubMed
  36. Gut. 2010 May;59(5):638-44 - PubMed
  37. Eur Radiol. 2011 Jun;21(6):1233-42 - PubMed
  38. Invest Radiol. 2008 Jul;43(7):504-11 - PubMed
  39. Eur Radiol. 2011 Oct;21(10):2056-66 - PubMed
  40. Eur Radiol. 2009 Oct;19(10):2456-66 - PubMed
  41. Hepatology. 2005 Nov;42(5):1208-36 - PubMed
  42. Cancer Epidemiol Biomarkers Prev. 2002 Apr;11(4):369-76 - PubMed
  43. J Magn Reson Imaging. 2010 Feb;31(2):356-64 - PubMed
  44. Hum Pathol. 1991 Feb;22(2):172-8 - PubMed

Publication Types