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Amino Acids. 1995 Dec;8(4):385-91. doi: 10.1007/BF00806556.

The oxidation of oxytocin and vasopressin by peroxidase/H2O 2 system.

Amino acids

M A Rosei, R Coccia, C Blarzino, C Foppoli, L Mosca

Affiliations

  1. Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Università "La Sapienza", P.le A. Moro, 5, I-00185, Roma, Italy.

PMID: 24186516 DOI: 10.1007/BF00806556

Abstract

Oxytocin and vasopressin are oxidized by horseradish peroxidase and by lactoperoxidase, in the presence of hydrogen peroxide. Spectrophotometric measurements are indicative of the formation of dityrosine. Kinetic parameters indicate that the affinity of horseradish peroxidase is slightly higher for oxytocin with respect to vasopressin and that the two hormones are better substrates for both peroxidases than free tyrosine.

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