Display options
Cite
Light KJ, Allison J. Mechanistic considerations of the protonation and fragmentation of highly functionalized molecules in fast atom bombardment: High resolution mass spectrometry and tandem mass spectrometry analysis of the ions formed by fast atom bombardment of digoxin and related cardiac glycosides. J Am Soc Mass Spectrom. 1990;1(6):455-72doi: 10.1016/1044-0305(90)85029-L.
Light, K. J., & Allison, J. (1990). Mechanistic considerations of the protonation and fragmentation of highly functionalized molecules in fast atom bombardment: High resolution mass spectrometry and tandem mass spectrometry analysis of the ions formed by fast atom bombardment of digoxin and related cardiac glycosides. Journal of the American Society for Mass Spectrometry, 1(6), 455-72. https://doi.org/10.1016/1044-0305(90)85029-L
Light, K J, and Allison, J. "Mechanistic considerations of the protonation and fragmentation of highly functionalized molecules in fast atom bombardment: High resolution mass spectrometry and tandem mass spectrometry analysis of the ions formed by fast atom bombardment of digoxin and related cardiac glycosides." Journal of the American Society for Mass Spectrometry vol. 1,6 (1990): 455-72. doi: https://doi.org/10.1016/1044-0305(90)85029-L
Light KJ, Allison J. Mechanistic considerations of the protonation and fragmentation of highly functionalized molecules in fast atom bombardment: High resolution mass spectrometry and tandem mass spectrometry analysis of the ions formed by fast atom bombardment of digoxin and related cardiac glycosides. J Am Soc Mass Spectrom. 1990 Nov;1(6):455-72. doi: 10.1016/1044-0305(90)85029-L. PMID: 24248980.
Copy Download .nbib Format: NLM
Share it on

J Am Soc Mass Spectrom. 1990 Nov;1(6):455-72. doi: 10.1016/1044-0305(90)85029-L.

Mechanistic considerations of the protonation and fragmentation of highly functionalized molecules in fast atom bombardment: High resolution mass spectrometry and tandem mass spectrometry analysis of the ions formed by fast atom bombardment of digoxin and related cardiac glycosides.

Journal of the American Society for Mass Spectrometry

K J Light, J Allison

Affiliations

  1. Department of Chemistry, Michigan State University, 48824, East Lansing, MI, USA.

PMID: 24248980 DOI: 10.1016/1044-0305(90)85029-L

Abstract

High resolution mass spectrometry and tandem mass spectrometry analyses of the major ions of digoxin formed by fast atom bombardment are presented and discussed to investigate the mechanisms through which fragment ions are formed. Similar cardiac glycosides are also analyzed to provide support for the proposed fragment assignments. Remote site fragmentation with the charge localized on the aglycone portion of the molecule may provide an explanation for the fragment ions observed in these studies because the majority of these ions contain the aglycone portion of the molecule. The results obtained parallel previously reported results from an ammonia chemical ionization mass spectral study of cardiac glycosides. (J Am Soc Mass Spectrom 1990, 1, 455-472).

References

  1. Anal Biochem. 1989 Feb 1;176(2):382-9 - PubMed
  2. J Am Chem Soc. 1976 Mar 17;98(6):1301-8 - PubMed
  3. Biomed Mass Spectrom. 1979 Oct;6(10):415-21 - PubMed
  4. Anal Biochem. 1986 Jun;155(2):286-307 - PubMed
  5. Biomed Environ Mass Spectrom. 1989 Mar;18(3):177-84 - PubMed

Publication Types