Display options
Cite
Bener A, Darwish S, Al-Hamaq AO, et al. Association of PPARγ2 gene variant Pro12Ala polymorphism with hypertension and obesity in the aboriginal Qatari population known for being consanguineous. Appl Clin Genet. 2013;6:103-11doi: 10.2147/TACG.S49875.
Bener, A., Darwish, S., Al-Hamaq, A. O., Mohammad, R. M., & Yousafzai, M. T. (2013). Association of PPARγ2 gene variant Pro12Ala polymorphism with hypertension and obesity in the aboriginal Qatari population known for being consanguineous. The application of clinical genetics, 6103-11. https://doi.org/10.2147/TACG.S49875
Bener, Abdulbari, et al. "Association of PPARγ2 gene variant Pro12Ala polymorphism with hypertension and obesity in the aboriginal Qatari population known for being consanguineous." The application of clinical genetics vol. 6 (2013): 103-11. doi: https://doi.org/10.2147/TACG.S49875
Bener A, Darwish S, Al-Hamaq AO, Mohammad RM, Yousafzai MT. Association of PPARγ2 gene variant Pro12Ala polymorphism with hypertension and obesity in the aboriginal Qatari population known for being consanguineous. Appl Clin Genet. 2013 Oct 24;6:103-11. doi: 10.2147/TACG.S49875. eCollection 2013. PMID: 24187509; PMCID: PMC3811883.
Copy Download .nbib Format: NLM
Share it on

Appl Clin Genet. 2013 Oct 24;6:103-11. doi: 10.2147/TACG.S49875. eCollection 2013.

Association of PPARγ2 gene variant Pro12Ala polymorphism with hypertension and obesity in the aboriginal Qatari population known for being consanguineous.

The application of clinical genetics

Abdulbari Bener, Sarah Darwish, Abdulla Oaa Al-Hamaq, Ramzi M Mohammad, Mohammad T Yousafzai

Affiliations

  1. Department of Medical Statistics and Epidemiology, Hamad Medical Corporation, Department of Public Health, Weill Cornell Medical College, Doha, Qatar ; Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, University of Manchester, Manchester, UK.

PMID: 24187509 PMCID: PMC3811883 DOI: 10.2147/TACG.S49875

Abstract

AIM: The aim of this study was to investigate the association of the Pro12Ala polymorphism of the human peroxisome proliferator-activated receptor gamma 2 (PPARγ2) gene with hypertension and obesity in a highly consanguineous aboriginal Qatari population.

DESIGN: A cross-sectional survey conducted from January 2011-December 2012.

SETTING: Primary health care clinics.

SUBJECTS: A random sample of 1,528 Qatari male and female population older than 20 years of age.

MATERIALS AND METHODS: Data on age, sex, income, level of education, occupation status, body mass index, and blood pressure and lipid profile were obtained. The Pro12Ala in the PPARγ2 gene was detected on the LightCycler® using two specific probes: (Sensor [G] 5'-CTC CTA TTG ACG CAG AAA GCG-FL and PPAR Anchor 5' LC Red 640- TCC TTC ACT GAT ACA CTG TCT GCA AAC ATA TC-PH). Univariate and multivariate logistic regression were performed.

RESULT: Out of a total 1,528 participants, 220 were diagnosed with essential hypertension, and 420 were obese. Participants with consanguinity were significantly higher among hypertensive than normotensive (41.9% versus 30.8%; P=0.001). Altogether, more than three-fourths (89%) of the participants had a wild genotype (Pro12Pro), 9.8% were heterozygous with Pro12Ala, and only 1.2% was homozygous with the Ala12Ala genotype. The frequency of the Pro allele was 94.5% in normotensive versus 90.5% in hypertensive, while the distribution of the Ala allele was 5.5% in normotensive versus 9.5% in the hypertensive group (P=0.001). The odds of hypertension were 1.7 times higher among the participants with the Ala allele as compared to those with the Pro, while adjusting for other potential confounders (adjusted odds ratio 1.69; 95% confidence interval 1.12-2.55; P=0.012). There was no association between the PPARγ2Ala allele and obesity (P=0.740).

CONCLUSION: The current study revealed an association between the PPARγ2Ala allele and hypertension in Qatar's population. On the other hand, this study found no association between the Ala allele and obesity.

Keywords: PPARγ2 gene; Pro12Ala polymorphism; consanguinity; hypertension; obesity

References

  1. Exp Gerontol. 2008 Dec;43(12):1108-13 - PubMed
  2. Diabetes. 2001 Mar;50(3):686-9 - PubMed
  3. J Med Genet. 2003 Oct;40(10):773-80 - PubMed
  4. J Nutr Sci Vitaminol (Tokyo). 2007 Jun;53(3):239-46 - PubMed
  5. Diabetes. 2002 Jul;51(7):2045-55 - PubMed
  6. J Clin Endocrinol Metab. 2001 Feb;86(2):536-41 - PubMed
  7. J Hum Hypertens. 2004 Jul;18(7):529-30 - PubMed
  8. Diabetes Metab Res Rev. 2005 Sep-Oct;21(5):465-9 - PubMed
  9. J Clin Endocrinol Metab. 2007 Feb;92(2):386-95 - PubMed
  10. J Hypertens. 2003 Sep;21(9):1657-62 - PubMed
  11. Diabetes. 1998 Apr;47(4):507-14 - PubMed
  12. Endocrinology. 2001 Jul;142(7):3125-34 - PubMed
  13. Nature. 1999 Dec 23-30;402(6764):880-3 - PubMed
  14. Cardiovasc Diabetol. 2011 Dec 14;10:112 - PubMed
  15. J Hum Hypertens. 2006 Sep;20(9):684-92 - PubMed
  16. Acta Diabetol. 2008 Mar;45(1):15-21 - PubMed
  17. J Obes. 2013;2013:269038 - PubMed
  18. Lab Invest. 2009 Aug;89(8):887-902 - PubMed
  19. Diabetologia. 1999 Sep;42(9):1033-49 - PubMed
  20. Lancet. 2000 Mar 18;355(9208):1008-10 - PubMed
  21. Diabetes. 2001 Apr;50(4):891-4 - PubMed
  22. Genet Mol Res. 2012 Aug 29;11(3):2929-38 - PubMed
  23. Metabolism. 2000 Oct;49(10):1267-70 - PubMed
  24. Diabetes. 2002 Aug;51(8):2341-7 - PubMed
  25. Food Nutr Bull. 2006 Mar;27(1):39-45 - PubMed
  26. J Biosoc Sci. 2010 Jan;42(1):59-82 - PubMed
  27. Hypertens Res. 2002 Jan;25(1):25-9 - PubMed
  28. Diabetes. 1998 Nov;47(11):1806-8 - PubMed
  29. Biochem Biophys Res Commun. 1997 Apr 28;233(3):756-9 - PubMed
  30. JAMA. 2003 May 21;289(19):2560-72 - PubMed
  31. Nature. 1990 Oct 18;347(6294):645-50 - PubMed
  32. J Biosoc Sci. 2006 Mar;38(2):239-46 - PubMed
  33. BMC Med Genet. 2005 Mar 22;6:11 - PubMed
  34. Am J Hum Genet. 2010 Jul 9;87(1):17-25 - PubMed

Publication Types