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Divakaran A, Narayanaswamy JC, Kalmadi SV, et al. Parent-of-origin Effect in Schizophrenia and Non-affective Psychoses: Evidence from Dermatoglyphics. Indian J Psychol Med. 2013;35(3):260-7doi: 10.4103/0253-7176.119481.
Divakaran, A., Narayanaswamy, J. C., Kalmadi, S. V., Narayan, V., Rao, N. P., & Venkatasubramanian, G. (2013). Parent-of-origin Effect in Schizophrenia and Non-affective Psychoses: Evidence from Dermatoglyphics. Indian journal of psychological medicine, 35(3), 260-7. https://doi.org/10.4103/0253-7176.119481
Divakaran, Anjith, et al. "Parent-of-origin Effect in Schizophrenia and Non-affective Psychoses: Evidence from Dermatoglyphics." Indian journal of psychological medicine vol. 35,3 (2013): 260-7. doi: https://doi.org/10.4103/0253-7176.119481
Divakaran A, Narayanaswamy JC, Kalmadi SV, Narayan V, Rao NP, Venkatasubramanian G. Parent-of-origin Effect in Schizophrenia and Non-affective Psychoses: Evidence from Dermatoglyphics. Indian J Psychol Med. 2013 Jul;35(3):260-7. doi: 10.4103/0253-7176.119481. PMID: 24249928; PMCID: PMC3821203.
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Indian J Psychol Med. 2013 Jul;35(3):260-7. doi: 10.4103/0253-7176.119481.

Parent-of-origin Effect in Schizophrenia and Non-affective Psychoses: Evidence from Dermatoglyphics.

Indian journal of psychological medicine

Anjith Divakaran, Janardhanan C Narayanaswamy, Sunil V Kalmadi, Vidya Narayan, Naren P Rao, Ganesan Venkatasubramanian

Affiliations

  1. Department of Psychiatry and Translational Psychiatry Laboratory, Cognitive Neurobiology Division, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

PMID: 24249928 PMCID: PMC3821203 DOI: 10.4103/0253-7176.119481

Abstract

OBJECTIVE: This study aims at examining "parent-of-origin effect" (POE) in dermatoglyphic patterns among patients with schizophrenia and non-affective psychoses.

MATERIALS AND METHODS: Dermatoglyphic comparison was carried out for schizophrenia patients (n=200) and healthy controls (HC) (n=100). In addition, the effect of family history and POE was examined in the dermatoglyphic pattern.

RESULTS: Schizophrenia patients compared to HC had significantly lower left total finger ridge count (LTFRC) (t=3.63, P<0.001), right total finger ridge count (RTFRC) (t=4.86, P<0.001), and absolute finger ridge count (ATFRC) (t=4.80, P<0.001) compared to HC. It was also noted that patient group had significantly higher average number of arches (t=2.20, P=0.03). The comparison between the same sex POE group and the opposite sex POE group revealed that significant differences exist in LTFRC (t=2.91, P<0.01) and ATFRC (t=2.30, P=0.02). The same sex group also had lesser number of whorls compared to opposite sex group (t=2.04, P=0.04).

CONCLUSIONS: The same sex parental inheritance group seem to be more developmentally compromised than the opposite sex parental inheritance group indicating a significant POE. Complex epigenetic mechanisms along with hormonal modulation could explain the sex specific disease phenotype expression, which is a plausible explanation as in the present study.

Keywords: Dermatoglyphics; epigenetic; neurodevelopmental; parent-of-origin effect; schizophrenia

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