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Kline CL, El-Deiry WS. Personalizing colon cancer therapeutics: targeting old and new mechanisms of action. Pharmaceuticals (Basel). 2013;6(8):988-1038doi: 10.3390/ph6080988.
Kline, C. L., & El-Deiry, W. S. (2013). Personalizing colon cancer therapeutics: targeting old and new mechanisms of action. Pharmaceuticals (Basel, Switzerland), 6(8), 988-1038. https://doi.org/10.3390/ph6080988
Kline, Christina Leah B, and El-Deiry, Wafik S. "Personalizing colon cancer therapeutics: targeting old and new mechanisms of action." Pharmaceuticals (Basel, Switzerland) vol. 6,8 (2013): 988-1038. doi: https://doi.org/10.3390/ph6080988
Kline CL, El-Deiry WS. Personalizing colon cancer therapeutics: targeting old and new mechanisms of action. Pharmaceuticals (Basel). 2013 Aug 21;6(8):988-1038. doi: 10.3390/ph6080988. PMID: 24276379; PMCID: PMC3817731.
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Pharmaceuticals (Basel). 2013 Aug 21;6(8):988-1038. doi: 10.3390/ph6080988.

Personalizing colon cancer therapeutics: targeting old and new mechanisms of action.

Pharmaceuticals (Basel, Switzerland)

Christina Leah B Kline, Wafik S El-Deiry

Affiliations

  1. Hematology/Oncology Division, Penn State Hershey Medical Center, Hershey, PA 17033, USA. [email protected].

PMID: 24276379 PMCID: PMC3817731 DOI: 10.3390/ph6080988

Abstract

The use of pharmaceuticals for colon cancer treatment has been increasingly personalized, in part due to the development of new molecular tools. In this review, we discuss the old and new colon cancer chemotherapeutics, and the parameters that have been shown to be predictive of efficacy and safety of these chemotherapeutics. In addition, we discuss how alternate pharmaceuticals have been developed in light of a potential lack of response or resistance to a particular chemotherapeutic.

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