Indian J Endocrinol Metab. 2013 Oct;17:S35-44. doi: 10.4103/2230-8210.119503.
Indian journal of endocrinology and metabolism
Manisha Sahay, Rakesh Sahay
PMID: 24251212 PMCID: PMC3830358 DOI: 10.4103/2230-8210.119503
Rickets/osteomalacia is an important problem in a tropical country. Many cases are due to poor vitamin D intake or calcium deficient diets and can be corrected by administration of calcium and vitamin D. However, some cases are refractory to vitamin D therapy and are related to renal defects. These include rickets of renal tubular acidosis (RTA), hypophosphatemic rickets, and vitamin D dependent rickets (VDDR). The latter is due to impaired action of 1α-hydroxylase in renal tubule. These varieties need proper diagnosis and specific treatment.
Keywords: Hypophosphatemic rickets; osteomalacia; renal rickets; renal tubular acidosis; rickets; vitamin D rickets