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Baker RL, Peterson AJ, Bass JJ, et al. Replicated selection for insulin-like growth factor-1 and body weight in mice. Theor Appl Genet. 1991;81(5):685-92doi: 10.1007/BF00226738.
Baker, R. L., Peterson, A. J., Bass, J. J., Amyes, N. C., Breier, B. H., & Gluckman, P. D. (1991). Replicated selection for insulin-like growth factor-1 and body weight in mice. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 81(5), 685-92. https://doi.org/10.1007/BF00226738
Baker, R L, et al. "Replicated selection for insulin-like growth factor-1 and body weight in mice." TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik vol. 81,5 (1991): 685-92. doi: https://doi.org/10.1007/BF00226738
Baker RL, Peterson AJ, Bass JJ, Amyes NC, Breier BH, Gluckman PD. Replicated selection for insulin-like growth factor-1 and body weight in mice. Theor Appl Genet. 1991 May;81(5):685-92. doi: 10.1007/BF00226738. PMID: 24221387.
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Theor Appl Genet. 1991 May;81(5):685-92. doi: 10.1007/BF00226738.

Replicated selection for insulin-like growth factor-1 and body weight in mice.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

R L Baker, A J Peterson, J J Bass, N C Amyes, B H Breier, P D Gluckman

Affiliations

  1. Ruakura Agricultural Centre, Ministry of Agriculture and Fisheries, Hamilton, New Zealand.

PMID: 24221387 DOI: 10.1007/BF00226738

Abstract

Five generations of divergent selection for plasma concentration of insulin-like growth factor-1 (IGF-1) and for 12-week body weight were carried out in mice, including randomly selected control lines for each trait. All lines were replicated once (12 lines in total). Each replicate line consisted of eight male and eight female parents per generation. Litter size was standardized to eight pups at birth. Mass selection was applied in the selected lines and within-family random selection in the control lines. Blood was taken from the orbital sinus of individual mice at 12 weeks of age for IGF-1 assay. Realized heritabilities were 0.10±0.01 for IGF-1 and 0.41 ± 0.02 for 12-week weight. The realized genetic correlation between IGF-1 and 12-week weight was 0.58 ± 0.01, with a phenotypic correlation of 0.38. Although the genetic correlation between IGF-1 and body weight in mice is moderately positive, 12-week weight responded 3.5 times as fast to weight selection as to selection for IGF-1.

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