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Sunderman FW. Mechanisms of metal carcinogenesis. Biol Trace Elem Res. 1979;1(1):63-86doi: 10.1007/BF02783844.
Sunderman, F. W. (1979). Mechanisms of metal carcinogenesis. Biological trace element research, 1(1), 63-86. https://doi.org/10.1007/BF02783844
Sunderman, F W. "Mechanisms of metal carcinogenesis." Biological trace element research vol. 1,1 (1979): 63-86. doi: https://doi.org/10.1007/BF02783844
Sunderman FW. Mechanisms of metal carcinogenesis. Biol Trace Elem Res. 1979 Mar;1(1):63-86. doi: 10.1007/BF02783844. PMID: 24276983.
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Biol Trace Elem Res. 1979 Mar;1(1):63-86. doi: 10.1007/BF02783844.

Mechanisms of metal carcinogenesis.

Biological trace element research

F W Sunderman

Affiliations

  1. Department of Laboratory Medicine, University of Connecticut School of Medicine, 06032, Farmington, Connecticut.

PMID: 24276983 DOI: 10.1007/BF02783844

Abstract

Experimental observations that pertain to mechanisms of metal carcinogenesis are summarized, with emphasis upon (a) interactions of metals with nucleic acids in vitro; (b) impairment by metals of the fidelity of DNA replication by DNA polymerase in vitro; (c) mutagenicity of metals in microorganisms; (d) cytogenetic aberrations induced by metals in tissue culture cells; (e) induction by metals of neoplastic transformation of tissue culture cells; and (f) nuclear uptake of metals in vivo and concomitant inhibitory effects of metals on synthesis of nucleic acids. Considered in toto, the experimental data support the somatic mutation hypothesis of chemical carcinogenesis. Sufficient experimental evidence is available regarding four carcinogenic metals (As, Be, Cr, and Ni) to permit speculations about the molecular reactions whereby these metals may induce somatic mutations.

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