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Rocci ML, Mojaverian P, Saccar CL. Morphine inhibition of theophylline clearance. Pharm Res. 1984;1(5):231-3doi: 10.1023/A:1016329515327.
Rocci, M. L., Mojaverian, P., & Saccar, C. L. (1984). Morphine inhibition of theophylline clearance. Pharmaceutical research, 1(5), 231-3. https://doi.org/10.1023/A:1016329515327
Rocci, M L, et al. "Morphine inhibition of theophylline clearance." Pharmaceutical research vol. 1,5 (1984): 231-3. doi: https://doi.org/10.1023/A:1016329515327
Rocci ML, Mojaverian P, Saccar CL. Morphine inhibition of theophylline clearance. Pharm Res. 1984 Sep;1(5):231-3. doi: 10.1023/A:1016329515327. PMID: 24277335.
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Pharm Res. 1984 Sep;1(5):231-3. doi: 10.1023/A:1016329515327.

Morphine inhibition of theophylline clearance.

Pharmaceutical research

M L Rocci, P Mojaverian, C L Saccar

Affiliations

  1. Division of Clinical Pharmacology, USA.

PMID: 24277335 DOI: 10.1023/A:1016329515327

Abstract

The effects of morphine on the single dose pharmacokinetics of theophylline were examined in two groups (6 rats/group) of male Sprague-Dawley rats after the administration of theophylline (6.25 mg/kg) alone and in conjunction with a 5 mg /kg I.V. dose of morphine sulfate. Concomitant morphine administration resulted in a 55 % reduction in theophylline clearance (0.14 ± 0.04 vs. 0.31 ± 0.061 · h(-1) kg(-1); p. < 0.0005). The reduction in theophylline clearance with morphine administration was accompanied by a significant prolongation in theophylline half-life (3.5 ± 1.5 vs. 1.4 ± 0.35 h; p < 0.02). No changes in the volume of distribution of theophylline occurred with co-administration of morphine. The mechanism of this pharmacokinetic interaction may be partially related to competition between theophylline and morphine for enzymes which metabolize these compounds.

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