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Chapman JM, Wyrick SD, Maguire JH, et al. Hypolipidemic Agents of Phthalimide Derivatives 6. Effects of Aromatic vs. Non-Aromatic Imides. Pharm Res. 1984;1(6):267-9doi: 10.1023/A:1016346018962.
Chapman, J. M., Wyrick, S. D., Maguire, J. H., Cocolas, G. H., & Hall, I. H. (1984). Hypolipidemic Agents of Phthalimide Derivatives 6. Effects of Aromatic vs. Non-Aromatic Imides. Pharmaceutical research, 1(6), 267-9. https://doi.org/10.1023/A:1016346018962
Chapman, J M, et al. "Hypolipidemic Agents of Phthalimide Derivatives 6. Effects of Aromatic vs. Non-Aromatic Imides." Pharmaceutical research vol. 1,6 (1984): 267-9. doi: https://doi.org/10.1023/A:1016346018962
Chapman JM, Wyrick SD, Maguire JH, Cocolas GH, Hall IH. Hypolipidemic Agents of Phthalimide Derivatives 6. Effects of Aromatic vs. Non-Aromatic Imides. Pharm Res. 1984 Nov;1(6):267-9. doi: 10.1023/A:1016346018962. PMID: 24277360.
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Pharm Res. 1984 Nov;1(6):267-9. doi: 10.1023/A:1016346018962.

Hypolipidemic Agents of Phthalimide Derivatives 6. Effects of Aromatic vs. Non-Aromatic Imides.

Pharmaceutical research

J M Chapman, S D Wyrick, J H Maguire, G H Cocolas, I H Hall

Affiliations

  1. Devision of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina at Chapel. Hill, Chapel Hill, North Carolina, 27514.

PMID: 24277360 DOI: 10.1023/A:1016346018962

Abstract

A number of substituted phthalimide, 1, 8-naphthalimide, succinimide and glutarimide derivatives demonstrated significant hypolipidemic activity at 20 mg/kg/ day, I.P. after 16 days dosing. The N-(n-pentyl) succinimide proved to be the most potent analogue of the new compounds, lowering serum triglyceride levels 51 % and serum cholesterol 47 % after 16 days dosing in mice. For the N-substituted derivatives, i. e., n-butyl, butanone, and propionic acid, of these four cyclic imides, there appeared to be no obvious trend in ability to reduce serum lipid levels. In general, the 1,8-naphthalimide and glutarimide derivatives appeared to be less active than phthalimide and succinimide. However, the α-phenylsuccinimide afforded less activity than the α-phenylglutarimide. Most of the derivatives at 20mg/kg/day demonstrated improved activity over clofibrate at 150mg/kg/day.

References

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