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Ahn MY, Han JW, Yoon HJ, et al. Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema. Toxicol Res. 2012;28(4):249-53doi: 10.5487/TR.2012.28.4.249.
Ahn, M. Y., Han, J. W., Yoon, H. J., Hwang, J. S., & Young, Y. E. (2012). Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema. Toxicological research, 28(4), 249-53. https://doi.org/10.5487/TR.2012.28.4.249
Ahn, Mi Young, et al. "Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema." Toxicological research vol. 28,4 (2012): 249-53. doi: https://doi.org/10.5487/TR.2012.28.4.249
Ahn MY, Han JW, Yoon HJ, Hwang JS, Young YE. Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema. Toxicol Res. 2012 Dec;28(4):249-53. doi: 10.5487/TR.2012.28.4.249. PMID: 24278617; PMCID: PMC3834430.
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Toxicol Res. 2012 Dec;28(4):249-53. doi: 10.5487/TR.2012.28.4.249.

Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema.

Toxicological research

Mi Young Ahn, Jea Woong Han, Hyung Joo Yoon, Jae Sam Hwang, Yun Eun Young

Affiliations

  1. Department of Agricultural Biology, National Academy of Agricultural Science, RDA, Suwon, Korea.

PMID: 24278617 PMCID: PMC3834430 DOI: 10.5487/TR.2012.28.4.249

Abstract

In this study, we prepared alcohol extracts of the larva, pupa, queen, and cocoon (clony) of B. ignitus, B. terrestris, and B. h. sapporoensis, and tested the anti-inflammatory activity of the extracts by using a rat model of adjuvant-induced edema. The extracts derived from the queen of B. ignitus, the queen of B. terrestris, and the cocoon of B. ignitus decreased hind paw edema after 1 day of i.p. administration. These extracts also induced vasorelaxation and NO production in calf pulmonary artery endothelial cells. These results suggest that bumblebee alcohol extracts has anti-inflammatory and vasorelaxant properties.

Keywords: Bumblebee alcohol extract; Edema

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