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Kim KW, Won YL, Ko KS, et al. The effects of hazardous chemical exposure on cardiovascular disease in chemical products manufacturing workers. Toxicol Res. 2012;28(4):269-77doi: 10.5487/TR.2012.28.4.269.
Kim, K. W., Won, Y. L., Ko, K. S., Heo, K. H., & Chung, Y. H. (2012). The effects of hazardous chemical exposure on cardiovascular disease in chemical products manufacturing workers. Toxicological research, 28(4), 269-77. https://doi.org/10.5487/TR.2012.28.4.269
Kim, Ki-Woong, et al. "The effects of hazardous chemical exposure on cardiovascular disease in chemical products manufacturing workers." Toxicological research vol. 28,4 (2012): 269-77. doi: https://doi.org/10.5487/TR.2012.28.4.269
Kim KW, Won YL, Ko KS, Heo KH, Chung YH. The effects of hazardous chemical exposure on cardiovascular disease in chemical products manufacturing workers. Toxicol Res. 2012 Dec;28(4):269-77. doi: 10.5487/TR.2012.28.4.269. PMID: 24278620; PMCID: PMC3834428.
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Toxicol Res. 2012 Dec;28(4):269-77. doi: 10.5487/TR.2012.28.4.269.

The effects of hazardous chemical exposure on cardiovascular disease in chemical products manufacturing workers.

Toxicological research

Ki-Woong Kim, Yong Lim Won, Kyung Sun Ko, Kyung-Hwa Heo, Yong Hyun Chung

Affiliations

  1. Occupational Safety and Health Research Institute, KOSHA, Daejeon, Korea.

PMID: 24278620 PMCID: PMC3834428 DOI: 10.5487/TR.2012.28.4.269

Abstract

The purpose of this study was to understand the mechanism of cardiovascular disease (CVD) caused by exposure to hazardous chemicals. We investigated changes in the symptoms of metabolic syndrome, which is strongly related to CVD, and in levels of other CVD risk factors, with a special emphasis on the roles of catecholamines and oxidative stress. The results revealed that neither body mass index (BMI) nor waist and hip circumferences were associated with exposure to hazardous chemicals. Among metabolic syndrome criteria, only HDL-cholesterol level increased on exposure to hazardous chemicals. Levels of epinephrine (EP) and norepinephrine (NEP) were not influenced by exposure to hazardous chemicals; however, the total antioxidative capacity (TAC) reduced because of increased oxidative stress. Both hazardous chemical exposure level and metabolite excretion were related to EP, NEP, and the oxidative stress index (OSI). Logistic regression analysis with these factors as independent variables and metabolic syndrome criteria as dependent variables revealed that EP was associated with blood pressure, and NEP with metabolic syndrome in the chemicalexposed group. In conclusion, the results suggest that reactive oxygen species generated and oxidative stress due to exposure to hazardous chemicals act as mediators and cause changes in the physiological levels of EP and NEP to increase blood pressure. This ultimately leads to the development of CVD through increase in cholesterol, triglyceride, and blood glucose levels by lipid peroxidation.

Keywords: Cardiovascular disease; Catecholamine; Hazardous chemical; Workers

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