Display options
Cite
Huijts M, Duits A, van Oostenbrugge RJ, et al. Accumulation of MRI Markers of Cerebral Small Vessel Disease is Associated with Decreased Cognitive Function. A Study in First-Ever Lacunar Stroke and Hypertensive Patients. Front Aging Neurosci. 2013;5:72doi: 10.3389/fnagi.2013.00072.
Huijts, M., Duits, A., van Oostenbrugge, R. J., Kroon, A. A., de Leeuw, P. W., & Staals, J. (2013). Accumulation of MRI Markers of Cerebral Small Vessel Disease is Associated with Decreased Cognitive Function. A Study in First-Ever Lacunar Stroke and Hypertensive Patients. Frontiers in aging neuroscience, 572. https://doi.org/10.3389/fnagi.2013.00072
Huijts, Marjolein, et al. "Accumulation of MRI Markers of Cerebral Small Vessel Disease is Associated with Decreased Cognitive Function. A Study in First-Ever Lacunar Stroke and Hypertensive Patients." Frontiers in aging neuroscience vol. 5 (2013): 72. doi: https://doi.org/10.3389/fnagi.2013.00072
Huijts M, Duits A, van Oostenbrugge RJ, Kroon AA, de Leeuw PW, Staals J. Accumulation of MRI Markers of Cerebral Small Vessel Disease is Associated with Decreased Cognitive Function. A Study in First-Ever Lacunar Stroke and Hypertensive Patients. Front Aging Neurosci. 2013 Nov 06;5:72. doi: 10.3389/fnagi.2013.00072. eCollection 2013. PMID: 24223555; PMCID: PMC3818574.
Copy Download .nbib Format: NLM
Share it on

Front Aging Neurosci. 2013 Nov 06;5:72. doi: 10.3389/fnagi.2013.00072. eCollection 2013.

Accumulation of MRI Markers of Cerebral Small Vessel Disease is Associated with Decreased Cognitive Function. A Study in First-Ever Lacunar Stroke and Hypertensive Patients.

Frontiers in aging neuroscience

Marjolein Huijts, Annelien Duits, Robert J van Oostenbrugge, Abraham A Kroon, Peter W de Leeuw, Julie Staals

Affiliations

  1. Department of Neurology, Maastricht University , Maastricht , Netherlands ; School for Mental Health and Neuroscience (MHeNS), Maastricht University , Maastricht , Netherlands ; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , Maastricht , Netherlands.

PMID: 24223555 PMCID: PMC3818574 DOI: 10.3389/fnagi.2013.00072

Abstract

BACKGROUND: White matter lesions (WMLs), asymptomatic lacunar infarcts, brain microbleeds (BMBs), and enlarged perivascular spaces (EPVS) have been identified as silent lesions due to cerebral small vessel disease (cSVD). All these markers have been individually linked to cognitive functioning, but are also strongly correlated with each other. The combined effect of these markers on cognitive function has never been studied and would possibly provide more useful information on the effect on cognitive function.

METHODS: Brain MRI and extensive neuropsychological assessment were performed in 189 patients at risk for cSVD (112 hypertensive patients and 77 first-ever lacunar stroke patients). We rated the presence of any asymptomatic lacunar infarct, extensive WMLs, any deep BMB, and moderate to extensive EPVS in the basal ganglia. The presence of each marker was summed to an ordinal score between 0 and 4. Associations with domains of cognitive function (memory, executive function, information processing speed, and overall cognition) were analyzed with correlation analyses.

RESULTS: Correlation analyses revealed significant associations between accumulating cSVD burden and decreased performance on all cognitive domains (all p ≤ 0.001). RESULTS remained significant for information processing speed (r = -0.181, p = 0.013) and overall cognition (r = -0.178, p = 0.017), after correction for age and sex. Testing of trend using linear regression analyses revealed the same results.

DISCUSSION: We tested a new approach to capture total brain damage resulting from cSVD and found that accumulation of MRI burden of cSVD is associated with decreased performance on tests of information processing speed and overall cognition, implying that accumulating brain damage is accompanied by worse cognitive functioning.

Keywords: brain microbleeds; cerebral small vessel disease; cognition; enlarged perivascular spaces; lacunar infarcts; white matter lesions

References

  1. J Gerontol A Biol Sci Med Sci. 2009 Jan;64(1):118-24 - PubMed
  2. Brain. 2004 Oct;127(Pt 10):2265-75 - PubMed
  3. Lancet Neurol. 2013 May;12(5):483-97 - PubMed
  4. Lancet Neurol. 2010 Sep;9(9):895-905 - PubMed
  5. J Gen Psychol. 1985 Apr;112(2):201-10 - PubMed
  6. Neurology. 2011 May 31;76(22):1872-8 - PubMed
  7. J Neurol. 1998 Feb;245(2):116-22 - PubMed
  8. Stroke. 2010 Mar;41(3):450-4 - PubMed
  9. Neurology. 1993 Sep;43(9):1683-9 - PubMed
  10. Brain. 2005 Sep;128(Pt 9):2034-41 - PubMed
  11. J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):149-53 - PubMed
  12. Stroke. 2002 Aug;33(8):2072-6 - PubMed
  13. J Hypertens. 2009 Jul;27(7):1446-52 - PubMed
  14. Neuropathol Appl Neurobiol. 2012 Jun;38(4):337-43 - PubMed
  15. Neurology. 2008 Apr 1;70(14):1208-14 - PubMed
  16. J Alzheimers Dis. 2010;22(2):663-72 - PubMed
  17. AJR Am J Roentgenol. 1987 Aug;149(2):351-6 - PubMed
  18. Stroke. 2008 Feb;39(2):397-402 - PubMed
  19. Acad Radiol. 2008 Jul;15(7):895-900 - PubMed
  20. Neuroepidemiology. 2012;38(1):41-7 - PubMed
  21. Lancet Neurol. 2007 Jul;6(7):611-9 - PubMed
  22. J Neurol Sci. 2005 Mar 15;229-230:13-20 - PubMed
  23. Stroke. 2006 Oct;37(10):2633-6 - PubMed
  24. Lancet Neurol. 2010 Jul;9(7):689-701 - PubMed
  25. Neurology. 2012 Jan 31;78(5):326-33 - PubMed

Publication Types