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Yang LC, Lu TJ, Lin WC. A Type II Arabinogalactan from Anoectochilus formosanus for G-CSF Production in Macrophages and Leukopenia Improvement in CT26-Bearing Mice Treated with 5-Fluorouracil. Evid Based Complement Alternat Med. 2013;2013:458075doi: 10.1155/2013/458075.
Yang, L. C., Lu, T. J., & Lin, W. C. (2013). A Type II Arabinogalactan from Anoectochilus formosanus for G-CSF Production in Macrophages and Leukopenia Improvement in CT26-Bearing Mice Treated with 5-Fluorouracil. Evidence-based complementary and alternative medicine : eCAM, 2013458075. https://doi.org/10.1155/2013/458075
Yang, Li-Chan, et al. "A Type II Arabinogalactan from Anoectochilus formosanus for G-CSF Production in Macrophages and Leukopenia Improvement in CT26-Bearing Mice Treated with 5-Fluorouracil." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 458075. doi: https://doi.org/10.1155/2013/458075
Yang LC, Lu TJ, Lin WC. A Type II Arabinogalactan from Anoectochilus formosanus for G-CSF Production in Macrophages and Leukopenia Improvement in CT26-Bearing Mice Treated with 5-Fluorouracil. Evid Based Complement Alternat Med. 2013;2013:458075. doi: 10.1155/2013/458075. Epub 2013 Sep 26. PMID: 24191166; PMCID: PMC3804054.
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Evid Based Complement Alternat Med. 2013;2013:458075. doi: 10.1155/2013/458075. Epub 2013 Sep 26.

A Type II Arabinogalactan from Anoectochilus formosanus for G-CSF Production in Macrophages and Leukopenia Improvement in CT26-Bearing Mice Treated with 5-Fluorouracil.

Evidence-based complementary and alternative medicine : eCAM

Li-Chan Yang, Ting-Jang Lu, Wen-Chuan Lin

Affiliations

  1. Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.

PMID: 24191166 PMCID: PMC3804054 DOI: 10.1155/2013/458075

Abstract

Anoectochilus formosanus is an herb well known in Asian countries. The polysaccharide isolated from A. formosanus consists of type II arabinogalactan (AGAF), with branched 3,6-Gal as the major moiety. In this study, AGAF was examined for the granulocyte colony-stimulating factor (G-CSF) production and related protein expression in RAW 264.7 murine macrophages. The signaling pathway of G-CSF production involves AGAF and mitogen-activated protein kinases (MAPKs) inhibitors and pattern-recognition receptor antibodies. AGAF was evaluated to ease the leukopenia in CT26-colon-cancer-bearing mice treated with 5-fluorouracil (5-FU). The results of this study showed that AGAF was a stimulant for Toll-like receptor 2 and Dectin-1 and that it induced G-CSF production, through p38 and ERK MAPK, and NF- κ B pathways. In vivo examination showed that the oral administration of AGAF mitigated the side effects of leukopenia caused by 5-FU in colon-cancer-bearing mice. In conclusion, the botanic type II AGAF in this study was a potent G-CSF inducer in vivo and in vitro.

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