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Nederbragt H, van Zutphen LF. Strain differences in kidney copper concentrations of male rats. Biol Trace Elem Res. 1987;14(3):217-23doi: 10.1007/BF02795688.
Nederbragt, H., & van Zutphen, L. F. (1987). Strain differences in kidney copper concentrations of male rats. Biological trace element research, 14(3), 217-23. https://doi.org/10.1007/BF02795688
Nederbragt, H, and van Zutphen, L F. "Strain differences in kidney copper concentrations of male rats." Biological trace element research vol. 14,3 (1987): 217-23. doi: https://doi.org/10.1007/BF02795688
Nederbragt H, van Zutphen LF. Strain differences in kidney copper concentrations of male rats. Biol Trace Elem Res. 1987 Dec;14(3):217-23. doi: 10.1007/BF02795688. PMID: 24254823.
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Biol Trace Elem Res. 1987 Dec;14(3):217-23. doi: 10.1007/BF02795688.

Strain differences in kidney copper concentrations of male rats.

Biological trace element research

H Nederbragt, L F van Zutphen

Affiliations

  1. Department of Pathology, Faculty of Veterinary Science, State University, Utrecht, The Netherlands.

PMID: 24254823 DOI: 10.1007/BF02795688

Abstract

The copper concentrations of the kidneys of male rats of six inbred (BN, F344, LEW, SHR, WAG/Cpb, and WAG/Rij) and one random-bred Wistar strain were determined.In inbred rats the mean concentration varied between strains and ranged from 7.10 μg/g for F 344 to 23.48 μg/g for WAG/Cpb. The calculated coefficient of genetic determination (g(2)) was 0.88. A remarkable discrepancy was found between the two WAG inbred strains; the WAG/Cpb had a 2.5 times higher kidney Cu concentration than the WAG/Rij.Kidney Cu concentrations of random-bred rats varied considerably; the coefficient of variation of the means was 28 and 34% in two samples taken with a 1-yr interval, respectively, indicating inhomogeneity within the population.The results indicate that the individual differences in kidney Cu concentration have a genetic basis.

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