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Yoon N, Kim KH, Park KH, et al. Preventive Effects of the Angiotensin-II Receptor Blocker on Atrial Remodeling in an Ischemic Heart Failure Model of Rats. Korean Circ J. 2013;43(10):686-93doi: 10.4070/kcj.2013.43.10.686.
Yoon, N., Kim, K. H., Park, K. H., Sim, D. S., Youn, H. J., Hong, Y. J., Park, H. W., Kim, J. H., Ahn, Y., Jeong, M. H., Cho, J. G., & Park, J. C. (2013). Preventive Effects of the Angiotensin-II Receptor Blocker on Atrial Remodeling in an Ischemic Heart Failure Model of Rats. Korean circulation journal, 43(10), 686-93. https://doi.org/10.4070/kcj.2013.43.10.686
Yoon, Namsik, et al. "Preventive Effects of the Angiotensin-II Receptor Blocker on Atrial Remodeling in an Ischemic Heart Failure Model of Rats." Korean circulation journal vol. 43,10 (2013): 686-93. doi: https://doi.org/10.4070/kcj.2013.43.10.686
Yoon N, Kim KH, Park KH, Sim DS, Youn HJ, Hong YJ, Park HW, Kim JH, Ahn Y, Jeong MH, Cho JG, Park JC. Preventive Effects of the Angiotensin-II Receptor Blocker on Atrial Remodeling in an Ischemic Heart Failure Model of Rats. Korean Circ J. 2013 Oct;43(10):686-93. doi: 10.4070/kcj.2013.43.10.686. Epub 2013 Oct 30. PMID: 24255653; PMCID: PMC3831015.
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Korean Circ J. 2013 Oct;43(10):686-93. doi: 10.4070/kcj.2013.43.10.686. Epub 2013 Oct 30.

Preventive Effects of the Angiotensin-II Receptor Blocker on Atrial Remodeling in an Ischemic Heart Failure Model of Rats.

Korean circulation journal

Namsik Yoon, Kye Hun Kim, Keun Ho Park, Doo Sun Sim, Hyun Ju Youn, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park

Affiliations

  1. Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea.

PMID: 24255653 PMCID: PMC3831015 DOI: 10.4070/kcj.2013.43.10.686

Abstract

BACKGROUND AND OBJECTIVES: It is widely known that angiotensin-II receptor blockers (ARBs) have reverse remodeling effects in atrium. Although atrial fibrillation is frequent in ischemic heart failure clinically, experiments to demonstrate ARB's effects on atrial remodeling in a heart failure model are rare.

MATERIALS AND METHODS: A heart failure model and a sham-operated group were formed in 25 Sprague-Dawley male rats of roughly 260 g in weight. Ischemic heart failure models were obtained via ligation of the left anterior descending coronary artery. In the ARB group, 30 mg/kg of losartan was administrated over a day for 4 weeks. Echocardiography was performed to measure left ventricle ejection fraction and left atrial diameter (LAD) at the baseline and 4 weeks after the operation. 4 weeks later, histologic and immunohistochemical evaluation were performed.

RESULTS: Groups were divided into the sham group, heart failure group, and heart failure-ARB group. We maintained 5 rats in each group for 4 weeks after operation. The decrease of left ventricular ejection fraction in the heart failure-ARB group was less than that in the heart failure group (p=0.023). The increase of LAD in the heart failure-ARB group was less than that in the heart failure group (p=0.025). Masson's trichrome stain revealed less fibrosis in the heart failure-ARB group. Immunohistochemical stain and western blot for connexin 43 showed less expression in the heart failure-ARB group.

CONCLUSION: In the ischemic heart failure model of rats, structurally and histologically, the ARB, losartan, has atrial reverse-remodeling effects. However, electrically, its role as an electrical stabilizer should be studied further.

Keywords: Angiotensin-II receptor blocker; Atrial fibrillation; Atrial remodeling

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