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Sompallae R, Hofmann O, Maher CA, et al. A comprehensive promoter landscape identifies a novel promoter for CD133 in restricted tissues, cancers, and stem cells. Front Genet. 2013;4:209doi: 10.3389/fgene.2013.00209.
Sompallae, R., Hofmann, O., Maher, C. A., Gedye, C., Behren, A., Vitezic, M., Daub, C. O., Devalle, S., Caballero, O. L., Carninci, P., Hayashizaki, Y., Lawlor, E. R., Cebon, J., & Hide, W. (2013). A comprehensive promoter landscape identifies a novel promoter for CD133 in restricted tissues, cancers, and stem cells. Frontiers in genetics, 4209. https://doi.org/10.3389/fgene.2013.00209
Sompallae, Ramakrishna, et al. "A comprehensive promoter landscape identifies a novel promoter for CD133 in restricted tissues, cancers, and stem cells." Frontiers in genetics vol. 4 (2013): 209. doi: https://doi.org/10.3389/fgene.2013.00209
Sompallae R, Hofmann O, Maher CA, Gedye C, Behren A, Vitezic M, Daub CO, Devalle S, Caballero OL, Carninci P, Hayashizaki Y, Lawlor ER, Cebon J, Hide W. A comprehensive promoter landscape identifies a novel promoter for CD133 in restricted tissues, cancers, and stem cells. Front Genet. 2013 Oct 29;4:209. doi: 10.3389/fgene.2013.00209. eCollection 2013. PMID: 24194746; PMCID: PMC3810939.
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Front Genet. 2013 Oct 29;4:209. doi: 10.3389/fgene.2013.00209. eCollection 2013.

A comprehensive promoter landscape identifies a novel promoter for CD133 in restricted tissues, cancers, and stem cells.

Frontiers in genetics

Ramakrishna Sompallae, Oliver Hofmann, Christopher A Maher, Craig Gedye, Andreas Behren, Morana Vitezic, Carsten O Daub, Sylvie Devalle, Otavia L Caballero, Piero Carninci, Yoshihide Hayashizaki, Elizabeth R Lawlor, Jonathan Cebon, Winston Hide

Affiliations

  1. Department of Biostatistics, Harvard School of Public Health Boston, MA, USA.

PMID: 24194746 PMCID: PMC3810939 DOI: 10.3389/fgene.2013.00209

Abstract

PROM1 is the gene encoding prominin-1 or CD133, an important cell surface marker for the isolation of both normal and cancer stem cells. PROM1 transcripts initiate at a range of transcription start sites (TSS) associated with distinct tissue and cancer expression profiles. Using high resolution Cap Analysis of Gene Expression (CAGE) sequencing we characterize TSS utilization across a broad range of normal and developmental tissues. We identify a novel proximal promoter (P6) within CD133(+) melanoma cell lines and stem cells. Additional exon array sampling finds P6 to be active in populations enriched for mesenchyme, neural stem cells and within CD133(+) enriched Ewing sarcomas. The P6 promoter is enriched with respect to previously characterized PROM1 promoters for a HMGI/Y (HMGA1) family transcription factor binding site motif and exhibits different epigenetic modifications relative to the canonical promoter region of PROM1.

Keywords: AC133 antigen; PROM1 protein; cancer stem cells; genetic; human; melanoma; promoter regions; transcription start site

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