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Grandi FC, An W. Non-LTR retrotransposons and microsatellites: Partners in genomic variation. Mob Genet Elements. 2013;3(4):e25674doi: 10.4161/mge.25674.
Grandi, F. C., & An, W. (2013). Non-LTR retrotransposons and microsatellites: Partners in genomic variation. Mobile genetic elements, 3(4), e25674. https://doi.org/10.4161/mge.25674
Grandi, Fiorella C, and An, Wenfeng. "Non-LTR retrotransposons and microsatellites: Partners in genomic variation." Mobile genetic elements vol. 3,4 (2013): e25674. doi: https://doi.org/10.4161/mge.25674
Grandi FC, An W. Non-LTR retrotransposons and microsatellites: Partners in genomic variation. Mob Genet Elements. 2013 Jul 01;3(4):e25674. doi: 10.4161/mge.25674. Epub 2013 Jul 11. PMID: 24195012; PMCID: PMC3812793.
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Mob Genet Elements. 2013 Jul 01;3(4):e25674. doi: 10.4161/mge.25674. Epub 2013 Jul 11.

Non-LTR retrotransposons and microsatellites: Partners in genomic variation.

Mobile genetic elements

Fiorella C Grandi, Wenfeng An

Affiliations

  1. School of Molecular Biosciences and Center for Reproductive Biology; Washington State University; Pullman, WA USA.

PMID: 24195012 PMCID: PMC3812793 DOI: 10.4161/mge.25674

Abstract

The human genome is laden with both non-LTR (long-terminal repeat) retrotransposons and microsatellite repeats. Both types of sequences are able to, either actively or passively, mutagenize the genomes of human individuals and are therefore poised to dynamically alter the human genomic landscape across generations. Non-LTR retrotransposons, such as L1 and Alu, are a major source of new microsatellites, which are born both concurrently and subsequently to L1 and Alu integration into the genome. Likewise, the mutation dynamics of microsatellite repeats have a direct impact on the fitness of their non-LTR retrotransposon parent owing to microsatellite expansion and contraction. This review explores the interactions and dynamics between non-LTR retrotransposons and microsatellites in the context of genomic variation and evolution.

Keywords: Alu; LINE-1; genomic instability; genomic variation; microsatellite; mononucleotide repeat; mutation rate; poly(A); retrotransposition; retrotransposon

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