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Joshaghani M, Nazari H, Ghasemi Falavarjani K, et al. Effect of Homatropine eye drops on pain after photorefractive keratectomy: A pilot study. Saudi J Ophthalmol. 2012;27(2):83-5doi: 10.1016/j.sjopt.2012.07.003.
Joshaghani, M., Nazari, H., Ghasemi Falavarjani, K., Shokrollahi, S., Jafar Ghaempanah, M., Abri Aghdam, K., & Mirbolouk Jalali, Z. (2013). Effect of Homatropine eye drops on pain after photorefractive keratectomy: A pilot study. Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society, 27(2), 83-5. https://doi.org/10.1016/j.sjopt.2012.07.003
Joshaghani, Mahmoud, et al. "Effect of Homatropine eye drops on pain after photorefractive keratectomy: A pilot study." Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society vol. 27,2 (2013): 83-5. doi: https://doi.org/10.1016/j.sjopt.2012.07.003
Joshaghani M, Nazari H, Ghasemi Falavarjani K, Shokrollahi S, Jafar Ghaempanah M, Abri Aghdam K, Mirbolouk Jalali Z. Effect of Homatropine eye drops on pain after photorefractive keratectomy: A pilot study. Saudi J Ophthalmol. 2013 Apr;27(2):83-5. doi: 10.1016/j.sjopt.2012.07.003. Epub 2012 Jul 31. PMID: 24227967; PMCID: PMC3809471.
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Saudi J Ophthalmol. 2013 Apr;27(2):83-5. doi: 10.1016/j.sjopt.2012.07.003. Epub 2012 Jul 31.

Effect of Homatropine eye drops on pain after photorefractive keratectomy: A pilot study.

Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society

Mahmoud Joshaghani, Hossein Nazari, Khalil Ghasemi Falavarjani, Siamak Shokrollahi, Mohammad Jafar Ghaempanah, Kaveh Abri Aghdam, Zahra Mirbolouk Jalali

Affiliations

  1. Eye Research Center and Eye Department, Rassoul Akram Hospital, Sattarkhan-Niaiesh St., Tehran University of Medical Sciences, Tehran, Iran.

PMID: 24227967 PMCID: PMC3809471 DOI: 10.1016/j.sjopt.2012.07.003

Abstract

PURPOSE: To assess the effect of homatropine eye drops on pain after photorefractive keratectomy (PRK).

METHODS: This randomized, double masked, interventional study included 15 patients (30 eyes) who underwent bilateral PRK. After operation, patients received homatropine eye drops, 4 times daily in only one eye (homatropine eye). The level of pain was evaluated using visual analogue scale (VAS), verbal rating scale (VRS) and pain rating index (PRI) at 0.5, 24 and 48 h after operation.

RESULTS: The level of pain was statistically similar between the two eyes half an hour after operation, however, homatropine eyes had significantly less pain 24 h after operation compared to fellow eyes (2.5 ± 1.9 vs 5.3 ± 2.5, P = 0.004 for VAS, 2.0 ± 1.2 vs 3.2 ± 0.9, P = 0.023 for VRS, and 9.4 ± 5.7 vs 16.0 ± 9.0, P = 0.031 for PRI). Also, 48 h after surgery, the pain scales were less in the homatropine eyes (2.3 ± 1.7 vs 4.0 ± 2.1, P = 0.014 for VAS, 1.6 ± 1.0 vs 2.5 ± 1.0, P = 0.038 for VRS, and 6.8 ± 5.7 vs 12.0 ± 8.9, P = 0.005 for PRI). No delayed epithelial healing was observed.

CONCLUSION: Homatropine eye drops may be useful for reducing pain after Photorefractive keratectomy.

Keywords: Mydriatics; Pain; Photorefractive keratectomy

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