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da Rosa L, Dantas-Corrêa EB, Narciso-Schiavon JL, et al. Diagnostic Performance of Two Point-of-Care Tests for Anti-HCV Detection. Hepat Mon. 2013;13(9):e12274doi: 10.5812/hepatmon.12274.
da Rosa, L., Dantas-Corrêa, E. B., Narciso-Schiavon, J. L., & Schiavon, L. d. e. . L. (2013). Diagnostic Performance of Two Point-of-Care Tests for Anti-HCV Detection. Hepatitis monthly, 13(9), e12274. https://doi.org/10.5812/hepatmon.12274
da Rosa, Lígia, et al. "Diagnostic Performance of Two Point-of-Care Tests for Anti-HCV Detection." Hepatitis monthly vol. 13,9 (2013): e12274. doi: https://doi.org/10.5812/hepatmon.12274
da Rosa L, Dantas-Corrêa EB, Narciso-Schiavon JL, Schiavon Lde L. Diagnostic Performance of Two Point-of-Care Tests for Anti-HCV Detection. Hepat Mon. 2013 Sep 10;13(9):e12274. doi: 10.5812/hepatmon.12274. eCollection 2013. PMID: 24282422; PMCID: PMC3830521.
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Hepat Mon. 2013 Sep 10;13(9):e12274. doi: 10.5812/hepatmon.12274. eCollection 2013.

Diagnostic Performance of Two Point-of-Care Tests for Anti-HCV Detection.

Hepatitis monthly

Lígia da Rosa, Esther Buzaglo Dantas-Corrêa, Janaína Luz Narciso-Schiavon, Leonardo de Lucca Schiavon

Affiliations

  1. Division of Gastroenterology, Federal University of Santa Catarina, Santa Catarina, Brazil.

PMID: 24282422 PMCID: PMC3830521 DOI: 10.5812/hepatmon.12274

Abstract

BACKGROUND: Besides the great importance of the issue in terms of public health, there is a lack of studies evaluating the performance of several of the currently used point of care tests (POCTs) for the detection of anti-HCV.

OBJECTIVES: To investigate the performance of two POCTs for anti-HCV detection and to assess the impact of the reading time on diagnostic performance.

PATIENTS AND METHODS: A total of 307 subjects were divided into three groups (1- HCV infected; 2- other chronic liver diseases; and 3- controls). The POCTs HCV Rapid Test Bioeasy® and Imuno-Rapido HCV® were read at 3, 5, 10, 15, 20 and 30 minutes. The sensitivity and specificity of the POCTs were calculated in relation to anti-HCV detection by chemiluminescence.

RESULTS: Valid results were obtained for all tests. When compared to the chemiluminescence, both tests showed sensitivity of 97.1% and specificity of 100%. No changes in the sensitivity or specificity of the tests were observed at different reading times and when patients with other chronic liver diseases were evaluated as a control group.

CONCLUSIONS: The POCTs evaluated in this study showed high sensitivity and specificity, with no change in the performance after the third minute of reading.

Keywords: Diagnosis; Hepatitis C; Point-of-Care Systems

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