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Rebolledo-Mendez JD, Vaishnav RA, Cooper NG, et al. Cross-kingdom sequence similarities between human micro-RNAs and plant viruses. Commun Integr Biol. 2013;6(5):e24951doi: 10.4161/cib.24951.
Rebolledo-Mendez, J. D., Vaishnav, R. A., Cooper, N. G., & Friedland, R. P. (2013). Cross-kingdom sequence similarities between human micro-RNAs and plant viruses. Communicative & integrative biology, 6(5), e24951. https://doi.org/10.4161/cib.24951
Rebolledo-Mendez, Jovan D, et al. "Cross-kingdom sequence similarities between human micro-RNAs and plant viruses." Communicative & integrative biology vol. 6,5 (2013): e24951. doi: https://doi.org/10.4161/cib.24951
Rebolledo-Mendez JD, Vaishnav RA, Cooper NG, Friedland RP. Cross-kingdom sequence similarities between human micro-RNAs and plant viruses. Commun Integr Biol. 2013 Sep 01;6(5):e24951. doi: 10.4161/cib.24951. Epub 2013 May 21. PMID: 24228136; PMCID: PMC3821693.
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Commun Integr Biol. 2013 Sep 01;6(5):e24951. doi: 10.4161/cib.24951. Epub 2013 May 21.

Cross-kingdom sequence similarities between human micro-RNAs and plant viruses.

Communicative & integrative biology

Jovan D Rebolledo-Mendez, Radhika A Vaishnav, Nigel G Cooper, Robert P Friedland

Affiliations

  1. Department of Biochemistry and Molecular Biology; University of Louisville, KY USA.

PMID: 24228136 PMCID: PMC3821693 DOI: 10.4161/cib.24951

Abstract

Micro-RNAs regulate the expression of cellular and tissue phenotypes at a post-transcriptional level through a complex process involving complementary interactions between micro-RNAs and messenger-RNAs. Similar nucleotide interactions have been shown to occur as cross-kingdom events; for example, between plant viruses and plant micro-RNAs and also between animal viruses and animal micro-RNAs. In this study, this view is expanded to look for cross-kingdom similarities between plant virus and human micro-RNA sequences. A method to identify significant nucleotoide sequence similarities between plant viruses and hsa micro-RNAs was created. Initial analyses demonstrate that plant viruses contain nucleotide sequences which exactly match the seed sequences of human micro-RNAs in both parallel and anti-parallel directions. For example, the bean common mosaic virus strain NL4 from Colombia contains sequences that match exactly the seed sequence for micro-RNA of the hsa-mir-1226 in the parallel direction, which suggests a cross-kingdom conservation. Similarly, the rice yellow stunt viral cRNA contains a sequence that is an exact match in the anti-parallel direction to the seed sequence of hsa-micro-RNA let-7b. The functional implications of these results need to be explored. The finding of these cross-kingdom sequence similarities is a useful starting point in support of bench level investigations.

Keywords: Tobacco mosaic virus; bioinformatics; environment; evolutionary conservation; health; human miRNA; molecular mimicry; plant virus; post-transcriptional regulation; sequence homology

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