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Wong JL, Muthuswamy R, Bartlett DL, et al. IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients. Oncoimmunology. 2013;2(9):e26245doi: 10.4161/onci.26245.
Wong, J. L., Muthuswamy, R., Bartlett, D. L., & Kalinski, P. (2013). IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients. Oncoimmunology, 2(9), e26245. https://doi.org/10.4161/onci.26245
Wong, Jeffrey L, et al. "IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients." Oncoimmunology vol. 2,9 (2013): e26245. doi: https://doi.org/10.4161/onci.26245
Wong JL, Muthuswamy R, Bartlett DL, Kalinski P. IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients. Oncoimmunology. 2013 Sep 01;2(9):e26245. doi: 10.4161/onci.26245. Epub 2013 Sep 12. PMID: 24228233; PMCID: PMC3820810.
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Oncoimmunology. 2013 Sep 01;2(9):e26245. doi: 10.4161/onci.26245. Epub 2013 Sep 12.

IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients.

Oncoimmunology

Jeffrey L Wong, Ravikumar Muthuswamy, David L Bartlett, Pawel Kalinski

Affiliations

  1. Department of Surgery; University of Pittsburgh; Pittsburgh, PA USA.

PMID: 24228233 PMCID: PMC3820810 DOI: 10.4161/onci.26245

Abstract

The effective accumulation and interaction of mature dendritic cells (DCs) and naïve T cells within lymph nodes (LNs), which are driven by the CCR7-CCL19/CCL21 chemokine axis, are critical for the induction of adaptive T-cell immunity. Human natural killer (NK) cells activated by interleukin (IL)-18 exhibit a unique 'helper' activity in promoting productive DC-T cell interactions, inducing DC maturation and shifting DC-primed T-cell responses toward a T

Keywords: CCL19; IL-18; adjuvant; colorectal cancer; dendritic cell; lymph node; natural killer cell

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