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Lang CJ, Brenner P, Heub D, et al. Neuropsychological status of mitochondrial encephalomyopathies. Eur J Neurol. 1995;2(3):171-6doi: 10.1111/j.1468-1331.1995.tb00112.x.
Lang, C. J., Brenner, P., Heub, D., Engelhardt, A., Reichmann, H., Seibel, P., & Neundörfer, B. (1995). Neuropsychological status of mitochondrial encephalomyopathies. European journal of neurology, 2(3), 171-6. https://doi.org/10.1111/j.1468-1331.1995.tb00112.x
Lang, C J, et al. "Neuropsychological status of mitochondrial encephalomyopathies." European journal of neurology vol. 2,3 (1995): 171-6. doi: https://doi.org/10.1111/j.1468-1331.1995.tb00112.x
Lang CJ, Brenner P, Heub D, Engelhardt A, Reichmann H, Seibel P, Neundörfer B. Neuropsychological status of mitochondrial encephalomyopathies. Eur J Neurol. 1995 Jul;2(3):171-6. doi: 10.1111/j.1468-1331.1995.tb00112.x. PMID: 24283633.
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Eur J Neurol. 1995 Jul;2(3):171-6. doi: 10.1111/j.1468-1331.1995.tb00112.x.

Neuropsychological status of mitochondrial encephalomyopathies.

European journal of neurology

C J Lang, P Brenner, D Heub, A Engelhardt, H Reichmann, P Seibel, B Neundörfer

Affiliations

  1. Neurological Hospital, University of Erlangen-Nuremberg at Erlangen, Schwabachanlage 6, D-91054 Erlangen, D-97080 Würzburg, GermanyNeurological Hospital, University of Würzburg, Josef-Schneider-Straße 11, D-97080 Würzburg, Germany.

PMID: 24283633 DOI: 10.1111/j.1468-1331.1995.tb00112.x

Abstract

We studied 15 patients suffering from mitochondrial encephalomyopathies (MEM) by a neuropsychological screening procedure. Eight of the patients were diagnosed as having progressive external ophthalmoplegia (PEO), four mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), and three Kearns-Sayre syndrome (KSS). Based on test results covering memory, orientation, non-verbal intelligence, drawing, arithmetics, word list generation, trail making and digit span, only four patients were regarded as normal, two in the PEO and two in the KSS groups, while five patients were found to be demented (two patients in the PEO and three patients in the MELAS groups). Although memory problems were very common, it is concluded that no uniform pattern of neuropsychological deficits is seen in MEM, that MELAS patients apparently are severely handicapped cognitively, and that considerable mental deterioration may be seen even with normal computer-assisted tomography findings.

1995 Lippincott Williams & Wilkins.

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