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Cravedi JP, Paris A, Perdu-Durand E, et al. Influence of growth hormone on the hepatic mixed function oxidase and transferase systems of rainbow trout. Fish Physiol Biochem. 1995;14(4):259-66doi: 10.1007/BF00004064.
Cravedi, J. P., Paris, A., Perdu-Durand, E., & Prunet, P. (1995). Influence of growth hormone on the hepatic mixed function oxidase and transferase systems of rainbow trout. Fish physiology and biochemistry, 14(4), 259-66. https://doi.org/10.1007/BF00004064
Cravedi, J P, et al. "Influence of growth hormone on the hepatic mixed function oxidase and transferase systems of rainbow trout." Fish physiology and biochemistry vol. 14,4 (1995): 259-66. doi: https://doi.org/10.1007/BF00004064
Cravedi JP, Paris A, Perdu-Durand E, Prunet P. Influence of growth hormone on the hepatic mixed function oxidase and transferase systems of rainbow trout. Fish Physiol Biochem. 1995 Aug;14(4):259-66. doi: 10.1007/BF00004064. PMID: 24197494.
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Fish Physiol Biochem. 1995 Aug;14(4):259-66. doi: 10.1007/BF00004064.

Influence of growth hormone on the hepatic mixed function oxidase and transferase systems of rainbow trout.

Fish physiology and biochemistry

J P Cravedi, A Paris, E Perdu-Durand, P Prunet

Affiliations

  1. INRA, Laboratoire des Xénobiotiques, B.P., 3 180, chemin de Tournefeuille, 31931, Toulouse Cédex, France.

PMID: 24197494 DOI: 10.1007/BF00004064

Abstract

The effect of GH treatment on hepatic cytochrome P450 content, aryl hydrocarbon hydroxylase (AHH), aminopyrine-N-demethylase (AND), testosterone hydroxylase, testosterone 5α- and 5β-reductase, UDP-glucuronyl transferase (UDPGT) and glutathione S-transferase (GST) activities in immature rainbow trout were investigated. Hepatic cytochrome P450 content, AHH and GST activities were measured in both GH implanted and GH injected animals whereas other activities were assayed in GH implanted trout only.GH implants significantly decreased cytochrome P450 content at 15 days compared to the control but no significant effect was observed at 15 or 30 d when GH was injected biweekly. In both cases, AHH activity was significantly decreased by GH treatment compared to the control whereas GST remained unchanged. Compared to the control, GH implanted fish exhibited a pronounced inhibition of AND, a decreased 6β and 16β-testosterone hydroxylation, an inhibition of UDPGT with testosterone as substrate and an enhanced 17β-testosterone oxidation.

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