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Graessmann M, Graessmann A, Hoffmann E, et al. The biological activity of different forms of Polyoma Virus DNA and viral DNA fragments. Mol Biol Rep. 1973;1(4):233-41doi: 10.1007/BF00357647.
Graessmann, M., Graessmann, A., Hoffmann, E., Niebel, J., & Pilaski, K. (1973). The biological activity of different forms of Polyoma Virus DNA and viral DNA fragments. Molecular biology reports, 1(4), 233-41. https://doi.org/10.1007/BF00357647
Graessmann, M, et al. "The biological activity of different forms of Polyoma Virus DNA and viral DNA fragments." Molecular biology reports vol. 1,4 (1973): 233-41. doi: https://doi.org/10.1007/BF00357647
Graessmann M, Graessmann A, Hoffmann E, Niebel J, Pilaski K. The biological activity of different forms of Polyoma Virus DNA and viral DNA fragments. Mol Biol Rep. 1973 Dec;1(4):233-41. doi: 10.1007/BF00357647. PMID: 24197572.
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Mol Biol Rep. 1973 Dec;1(4):233-41. doi: 10.1007/BF00357647.

The biological activity of different forms of Polyoma Virus DNA and viral DNA fragments.

Molecular biology reports

M Graessmann, A Graessmann, E Hoffmann, J Niebel, K Pilaski

Affiliations

  1. Institut für Molekularbiologie und Biochemie der Freien Universität Berlin, Berlin_W., F.R.G..

PMID: 24197572 DOI: 10.1007/BF00357647

Abstract

Mouse tissue culture cells were infected with different forms of Polyoma Virus (PV) DNA or virus DNA fragments by means of a microinjection technique and stained for PV-tumor (T) antigen and virus capsid (V) antigen 48 hr after injection.The efficiency of PV-DNA 1 (20S) to induce T- and V-antigen was within the same range as the efficiency of the full virus particle. DNA II (16S) showed a reduced capacity for both T- and V-antigen induction.Single stranded DNA molecules (16 or 18S) and double stranded DNA fragments (12S) led to T-antigen but not V-antigen synthesis. Simultaneous transfer of 16S and 18S DNA revealed T- and V-antigen formation.

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