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Eisenberg ML, Lee KL, Breyer BN, et al. Differences in quantitative urine composition in stone-forming versus unaffected mate kidneys. Open Access J Urol. 2009;1:9-13doi: 10.2147/rru.s6580.
Eisenberg, M. L., Lee, K. L., Breyer, B. N., Walsh, T. J., Konety, B. R., & Stoller, M. L. (2009). Differences in quantitative urine composition in stone-forming versus unaffected mate kidneys. Open access journal of urology, 19-13. https://doi.org/10.2147/rru.s6580
Eisenberg, Michael L, et al. "Differences in quantitative urine composition in stone-forming versus unaffected mate kidneys." Open access journal of urology vol. 1 (2009): 9-13. doi: https://doi.org/10.2147/rru.s6580
Eisenberg ML, Lee KL, Breyer BN, Walsh TJ, Konety BR, Stoller ML. Differences in quantitative urine composition in stone-forming versus unaffected mate kidneys. Open Access J Urol. 2009 Aug 24;1:9-13. doi: 10.2147/rru.s6580. eCollection 2009. PMID: 24198607; PMCID: PMC3806393.
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Open Access J Urol. 2009 Aug 24;1:9-13. doi: 10.2147/rru.s6580. eCollection 2009.

Differences in quantitative urine composition in stone-forming versus unaffected mate kidneys.

Open access journal of urology

Michael L Eisenberg, Keith L Lee, Benjamin N Breyer, Thomas J Walsh, Badrinath R Konety, Marshall L Stoller

Affiliations

  1. Department of Urology, University of California San Francisco, San Francisco, CA, USA;

PMID: 24198607 PMCID: PMC3806393 DOI: 10.2147/rru.s6580

Abstract

OBJECTIVES: Many patients present with bilateral stones. There is a unique group of patients, however, that presents with stones exclusively on one side. We hypothesize that in such situations, 24-hour urine collections may not reveal specific defects on the affected stone-bearing kidney. We therefore evaluated selective 12-hour urine collections after percutaneous nephrolithotomy (PNL) to help determine if there is differential renal excretion.

METHODS: We collected urine specimens from patients with nephrolithiasis who underwent unilateral PNL. Urine samples were collected and analyzed from nephrostomy tubes, representing the affected kidneys, and from Foley bladder catheters, representing the contralateral mate kidney.

RESULTS: Thirty-one patients were studied (14 with unilateral nephrolithiasis and 17 with bilateral). Treated kidneys from patients with unilateral nephrolithiasis displayed lowered urine excretion of uric acid, sodium, chloride, calcium, and total osmoles when compared to patients with bilateral nephrolithiasis. Stone size and length of procedure were not predictive of urine composition after PNL.

CONCLUSIONS: Treated kidneys from patients with a history of unilateral stone disease revealed marked differences in urine excretion compared to those with bilateral nephrolithiasis after unilateral PNL. These findings could be secondary to the surgical insult, urinary stone disease, or could be a responsible factor for stone pathogenesis.

Keywords: kidney; nephrolithiasis; percutaneous nephrolithotomy; stone

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