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Mulder KC, Lima LA, Miranda VJ, et al. Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides. Front Microbiol. 2013;4:321doi: 10.3389/fmicb.2013.00321.
Mulder, K. C., Lima, L. A., Miranda, V. J., Dias, S. C., & Franco, O. L. (2013). Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides. Frontiers in microbiology, 4321. https://doi.org/10.3389/fmicb.2013.00321
Mulder, Kelly C L, et al. "Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides." Frontiers in microbiology vol. 4 (2013): 321. doi: https://doi.org/10.3389/fmicb.2013.00321
Mulder KC, Lima LA, Miranda VJ, Dias SC, Franco OL. Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides. Front Microbiol. 2013 Oct 31;4:321. doi: 10.3389/fmicb.2013.00321. eCollection 2013. PMID: 24198814; PMCID: PMC3813893.
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Front Microbiol. 2013 Oct 31;4:321. doi: 10.3389/fmicb.2013.00321. eCollection 2013.

Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides.

Frontiers in microbiology

Kelly C L Mulder, Loiane A Lima, Vivian J Miranda, Simoni C Dias, Octávio L Franco

Affiliations

  1. Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília Brasília, Brazil.

PMID: 24198814 PMCID: PMC3813893 DOI: 10.3389/fmicb.2013.00321

Abstract

Cationic antimicrobial peptides (AMPs) and host defense peptides (HDPs) show vast potential as peptide-based drugs. Great effort has been made in order to exploit their mechanisms of action, aiming to identify their targets as well as to enhance their activity and bioavailability. In this review, we will focus on both naturally occurring and designed antiviral and antitumor cationic peptides, including those here called promiscuous, in which multiple targets are associated with a single peptide structure. Emphasis will be given to their biochemical features, selectivity against extra targets, and molecular mechanisms. Peptides which possess antitumor activity against different cancer cell lines will be discussed, as well as peptides which inhibit virus replication, focusing on their applications for human health, animal health and agriculture, and their potential as new therapeutic drugs. Moreover, the current scenario for production and the use of nanotechnology as delivery tool for both classes of cationic peptides, as well as the perspectives on improving them is considered.

Keywords: antitumor; antiviral; cationic peptides; target selectivity; therapeutic drugs

References

  1. Clin Colorectal Cancer. 2012 Sep;11(3):207-14 - PubMed
  2. Eur J Cancer. 2009 Mar;45(5):732-5 - PubMed
  3. J Biomed Biotechnol. 2005;2005(4):374-84 - PubMed
  4. Biochemistry. 1999 Mar 23;38(12):3850 - PubMed
  5. J Nat Prod. 2004 Sep;67(9):1577-9 - PubMed
  6. J Cell Biochem. 2012 Jan;113(1):184-93 - PubMed
  7. Peptides. 2011 Jan;32(1):11-9 - PubMed
  8. Chem Phys Lipids. 2011 Nov;164(8):766-81 - PubMed
  9. J Biol Chem. 2004 Apr 23;279(17):17951-6 - PubMed
  10. Cytopathology. 1995 Jun;6(3):162-7 - PubMed
  11. Cancer Res. 2005 Jun 1;65(11):4614-22 - PubMed
  12. Regul Pept. 2001 Sep 15;101(1-3):157-61 - PubMed
  13. Chemotherapy. 1991;37(5):327-34 - PubMed
  14. Acta Biochim Pol. 2011;58(1):111-7 - PubMed
  15. J Control Release. 2012 Apr 10;159(1):2-13 - PubMed
  16. Biotechnol Prog. 2013 May-Jun;29(3):681-7 - PubMed
  17. J Biol Chem. 1992 Aug 5;267(22):15301-9 - PubMed
  18. Nucleic Acids Res. 2005 Jul 20;33(13):4053-64 - PubMed
  19. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3792-6 - PubMed
  20. Mar Drugs. 2011;9(10):1995-2009 - PubMed
  21. Appl Microbiol Biotechnol. 2009 Oct;84(5):877-84 - PubMed
  22. J Cell Physiol. 2008 Sep;216(3):583-94 - PubMed
  23. Retrovirology. 2005 Jan 18;2:2 - PubMed
  24. Int J Pept Protein Res. 1994 Jun;43(6):573-82 - PubMed
  25. Hum Gene Ther. 1999 Apr 10;10(6):957-64 - PubMed
  26. Annu Rev Immunol. 1995;13:61-92 - PubMed
  27. Dev Comp Immunol. 2006;30(3):249-57 - PubMed
  28. Mol Cell Biochem. 2005 Aug;276(1-2):113-9 - PubMed
  29. J Biol Chem. 2009 Feb 6;284(6):3804-13 - PubMed
  30. Science. 2000 Aug 18;289(5482):1159-64 - PubMed
  31. Curr Eye Res. 2009 Mar;34(3):241-9 - PubMed
  32. Trends Biotechnol. 2011 Sep;29(9):464-72 - PubMed
  33. Biochem Pharmacol. 1990 Jun 15;39(12):1941-9 - PubMed
  34. Protein Expr Purif. 2007 Jun;53(2):293-301 - PubMed
  35. Crit Rev Toxicol. 2000 Sep;30(5):571-94 - PubMed
  36. Biochim Biophys Acta. 2006 Sep;1758(9):1351-8 - PubMed
  37. Eur J Clin Microbiol Infect Dis. 2000 Mar;19(3):187-94 - PubMed
  38. Antiviral Res. 2001 Dec;52(3):225-39 - PubMed
  39. Arch Pharm Res. 2013 Nov;36(11):1302-10 - PubMed
  40. Nat Rev Drug Discov. 2006 Mar;5(3):219-34 - PubMed
  41. Nat Biotechnol. 2013 May;31(5):379-82 - PubMed
  42. BMC Urol. 2008 Mar 03;8:5 - PubMed
  43. Fish Shellfish Immunol. 2010 Mar;28(3):434-9 - PubMed
  44. Cancer Lett. 1999 May 24;139(2):215-20 - PubMed
  45. Biochim Biophys Acta. 1997 Aug 29;1336(2):171-9 - PubMed
  46. Fed Proc. 1983 Jan;42(1):87-90 - PubMed
  47. Biochim Biophys Acta. 2009 Aug;1788(8):1582-92 - PubMed
  48. Eur J Biochem. 2001 Aug;268(15):4278-84 - PubMed
  49. Curr Pharm Des. 2004;10(19):2299-310 - PubMed
  50. Nature. 1981 Jul 16;292(5820):246-8 - PubMed
  51. Clin Microbiol Rev. 2006 Jul;19(3):491-511 - PubMed
  52. Cell Mol Life Sci. 2005 Apr;62(7-8):784-90 - PubMed
  53. Chem Biol Drug Des. 2013 Jan;81(1):136-47 - PubMed
  54. Eur Urol. 2006 Jul;50(1):141-7 - PubMed
  55. Adv Drug Deliv Rev. 2010 Dec 30;62(15):1456-67 - PubMed
  56. Curr Opin Chem Biol. 2013 Aug;17(4):546-54 - PubMed
  57. J Nat Prod. 2004 Sep;67(9):1522-7 - PubMed
  58. Peptides. 2012 Aug;36(2):257-65 - PubMed
  59. Mar Drugs. 2009 Sep 15;7(3):434-44 - PubMed
  60. J Nat Prod. 2002 Apr;65(4):487-91 - PubMed
  61. J Med Chem. 2006 Aug 10;49(16):4886-95 - PubMed
  62. J Mol Biol. 1999 Jan 8;285(1):333-45 - PubMed
  63. J Infect Dis. 1995 Aug;172(2):380-8 - PubMed
  64. Biochem Pharmacol. 1994 Jan 20;47(2):425-7 - PubMed
  65. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Apr 15;803(1):41-53 - PubMed
  66. Nature. 1994 Apr 14;368(6472):651-3 - PubMed
  67. J Virol. 2006 Apr;80(8):4038-46 - PubMed
  68. Oral Oncol. 2006 Aug;42(7):685-90 - PubMed
  69. Biochem Biophys Res Commun. 1997 Aug 28;237(3):624-8 - PubMed
  70. Peptides. 2012 Oct;37(2):294-300 - PubMed
  71. Chem Biol. 2004 Jun;11(6):817-33 - PubMed
  72. Cancer Biother Radiopharm. 2013 May;28(4):289-97 - PubMed
  73. Appl Microbiol Biotechnol. 2012 Sep;95(5):1191-8 - PubMed
  74. Oncol Lett. 2013 Feb;5(2):641-644 - PubMed
  75. FEBS Lett. 2011 Apr 6;585(7):995-1000 - PubMed
  76. Amino Acids. 2013 Mar;44(3):797-820 - PubMed
  77. Peptides. 2013 Apr;42:144-8 - PubMed
  78. Annu Rev Food Sci Technol. 2012;3:183-202 - PubMed
  79. J Membr Biol. 1985;87(1):35-44 - PubMed
  80. Exp Biol Med (Maywood). 2012 Apr;237(4):442-50 - PubMed
  81. Mar Drugs. 2011;9(10):1840-59 - PubMed
  82. Biochimie. 2013 Oct;95(10):1939-48 - PubMed
  83. J Virol. 2005 Sep;79(18):11598-606 - PubMed
  84. J Nat Prod. 2008 Jun;71(6):1052-4 - PubMed
  85. Biochim Biophys Acta. 2012 Jul;1820(7):1062-72 - PubMed
  86. J Clin Invest. 1985 Oct;76(4):1427-35 - PubMed
  87. Peptides. 2010 Jun;31(6):1026-33 - PubMed
  88. Biochim Biophys Acta. 1989 Aug 3;975(3):361-9 - PubMed
  89. Protein Expr Purif. 2008 Oct;61(2):168-74 - PubMed
  90. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5104-7 - PubMed
  91. Chem Pharm Bull (Tokyo). 2005 Mar;53(3):336-8 - PubMed
  92. Cancer Res. 2001 Nov 1;61(21):7709-12 - PubMed
  93. J Nat Prod. 2003 May;66(5):595-8 - PubMed
  94. Plant J. 1994 Jun;5(6):827-35 - PubMed
  95. Cancer Chemother Pharmacol. 1994;33(5):399-409 - PubMed
  96. Biotechnol Lett. 2011 Nov;33(11):2121-6 - PubMed
  97. FEBS J. 2006 Aug;273(15):3489-97 - PubMed
  98. J Clin Oncol. 2005 Nov 1;23(31):7871-80 - PubMed
  99. J Org Chem. 2006 Sep 15;71(19):7196-204 - PubMed
  100. Plant Biotechnol J. 2011 Jan;9(1):100-15 - PubMed
  101. Biopolymers. 2012;98(4):322-31 - PubMed
  102. Mar Biotechnol (NY). 2002 Jun;4(3):294-302 - PubMed
  103. AIDS Res Hum Retroviruses. 2003 Oct;19(10):875-81 - PubMed
  104. J Amino Acids. 2013;2013:939804 - PubMed
  105. J Virol. 2004 May;78(10):5147-56 - PubMed
  106. Appl Microbiol Biotechnol. 2006 Aug;71(5):661-7 - PubMed
  107. J Med Virol. 2002 Feb;66(2):229-34 - PubMed
  108. PLoS Pathog. 2010 Oct 28;6(10):e1001067 - PubMed
  109. Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12466-9 - PubMed
  110. J Dairy Res. 2007 May;74(2):233-8 - PubMed
  111. Int J Antimicrob Agents. 2004 Apr;23(4):382-9 - PubMed
  112. J Leukoc Biol. 1998 Jan;63(1):94-100 - PubMed
  113. Protein Expr Purif. 2006 Sep;49(1):39-46 - PubMed
  114. Oncogene. 1992 Feb;7(2):193-201 - PubMed
  115. J Antibiot (Tokyo). 1990 Dec;43(12):1524-32 - PubMed
  116. BioDrugs. 2013 Oct;27(5):479-93 - PubMed
  117. Mol Cancer Ther. 2005 Apr;4(4):612-24 - PubMed
  118. FASEB J. 2009 Dec;23(12):4299-307 - PubMed
  119. Biochim Biophys Acta. 2008 Feb;1778(2):357-75 - PubMed
  120. Expert Opin Investig Drugs. 2006 Aug;15(8):933-46 - PubMed
  121. Antiviral Res. 2001 Aug;51(2):141-9 - PubMed
  122. Antiviral Res. 2003 May;58(3):209-15 - PubMed
  123. Oncol Lett. 2013 Feb;5(2):483-488 - PubMed
  124. Cancer Chemother Pharmacol. 1999;43(6):507-15 - PubMed
  125. J Amino Acids. 2012;2012:967347 - PubMed
  126. Biochem Biophys Res Commun. 1998 Apr 17;245(2):549-53 - PubMed
  127. Org Biomol Chem. 2009 Oct 7;7(19):4037-44 - PubMed
  128. Antimicrob Agents Chemother. 1992 Jun;36(6):1249-55 - PubMed
  129. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61 - PubMed
  130. Eur J Biochem. 2003 Mar;270(6):1141-53 - PubMed
  131. Antiviral Res. 2004 Feb;61(2):101-9 - PubMed
  132. Eur J Pharmacol. 2009 Dec 25;625(1-3):190-4 - PubMed
  133. Fitoterapia. 2010 Jul;81(5):329-35 - PubMed
  134. Biochem Biophys Res Commun. 1998 Mar 6;244(1):253-7 - PubMed
  135. Anticancer Agents Med Chem. 2008 Aug;8(6):603-17 - PubMed
  136. PLoS One. 2013;8(1):e53491 - PubMed
  137. Biochem Biophys Res Commun. 1998 Dec 30;253(3):877-82 - PubMed
  138. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12628-32 - PubMed
  139. Antimicrob Agents Chemother. 1999 Jun;43(6):1317-23 - PubMed
  140. Trends Biotechnol. 1995 Jun;13(6):205-9 - PubMed
  141. Mol Immunol. 2013 Oct;55(3-4):264-74 - PubMed
  142. Science. 2000 Dec 1;290(5497):1721-6 - PubMed
  143. Biotechnol Prog. 2006 Mar-Apr;22(2):382-6 - PubMed
  144. Ciba Found Symp. 1994;186:197-216; discussion 216-23 - PubMed
  145. ACS Med Chem Lett. 2010 Jan 1;1(1):4-8 - PubMed
  146. Life Sci. 1999;64(12):1013-28 - PubMed
  147. Anticancer Res. 1998 Nov-Dec;18(6A):4467-74 - PubMed
  148. Chemistry. 2006 Oct 10;12(29):7615-26 - PubMed
  149. J Org Chem. 1996 Sep 20;61(19):6594-6600 - PubMed
  150. Biochemistry. 2004 Jul 6;43(26):8459-69 - PubMed
  151. J Am Chem Soc. 2008 May 21;130(20):6324-5 - PubMed
  152. Chemotherapy. 1991;37(3):206-11 - PubMed
  153. Am J Pathol. 2006 Nov;169(5):1753-66 - PubMed
  154. Peptides. 2012 Dec;38(2):446-56 - PubMed
  155. J Food Sci. 2010 Nov-Dec;75(9):H311-6 - PubMed
  156. PLoS One. 2012;7(3):e33639 - PubMed
  157. J Nat Prod. 2001 Jan;64(1):117-21 - PubMed
  158. Meat Sci. 2012 Jul;91(3):306-11 - PubMed
  159. J Gen Virol. 1998 Apr;79 ( Pt 4):731-40 - PubMed
  160. Oncogene. 1993 Apr;8(4):939-47 - PubMed
  161. Appl Microbiol Biotechnol. 2006 May;70(6):698-704 - PubMed
  162. Cell Mol Life Sci. 2005 Nov;62(22):2576-87 - PubMed
  163. Biotechnol Prog. 2010 Sep-Oct;26(5):1240-4 - PubMed
  164. J Virol. 1997 Aug;71(8):5997-6002 - PubMed
  165. Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-54 - PubMed
  166. Appl Microbiol Biotechnol. 2006 Sep;72(2):330-8 - PubMed
  167. J Virol. 1986 Dec;60(3):1068-74 - PubMed
  168. Biochem Pharmacol. 2002 Feb 15;63(4):707-15 - PubMed
  169. J Biol Chem. 2003 Jan 10;278(2):1310-5 - PubMed
  170. J Antibiot (Tokyo). 1988 Dec;41(12):1906-9 - PubMed
  171. Cell Mol Life Sci. 2005 Nov;62(22):2588-98 - PubMed
  172. Biochemistry. 1996 Sep 3;35(35):11361-8 - PubMed
  173. Peptides. 2006 Jun;27(6):1201-9 - PubMed
  174. AIDS. 1993 Aug;7(8):1129 - PubMed
  175. Eur J Biochem. 2000 Sep;267(17):5330-41 - PubMed
  176. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1813-8 - PubMed
  177. Antiviral Res. 2007 Sep;75(3):258-65 - PubMed
  178. Nat Biotechnol. 2006 Dec;24(12):1551-7 - PubMed
  179. Cell Immunol. 1998 Nov 1;189(2):107-15 - PubMed
  180. Lancet Infect Dis. 2001 Oct;1(3):156-64 - PubMed
  181. Science. 1981 May 22;212(4497):933-5 - PubMed
  182. Mol Cancer Ther. 2008 Jun;7(6):1588-97 - PubMed
  183. Antiviral Res. 2007 Nov;76(2):111-23 - PubMed
  184. Pharmacol Rev. 2003 Mar;55(1):27-55 - PubMed
  185. Appl Microbiol Biotechnol. 2006 Oct;72(6):1217-28 - PubMed
  186. Arch Virol. 1996;141(10):1875-89 - PubMed
  187. J Org Chem. 2000 Feb 11;65(3):782-92 - PubMed
  188. J Nat Prod. 2003 Jan;66(1):146-8 - PubMed
  189. J Pept Sci. 1998 Nov;4(7):413-25 - PubMed
  190. Biochemistry. 2003 Jun 3;42(21):6545-58 - PubMed
  191. Mem Inst Oswaldo Cruz. 2007 Jun;102(4):469-72 - PubMed
  192. Mol Cell Biol. 2002 Mar;22(6):1926-35 - PubMed
  193. PLoS One. 2012;7(10):e47047 - PubMed
  194. Cancer Lett. 2008 Nov 18;271(1):47-55 - PubMed
  195. Appl Microbiol Biotechnol. 2009 Aug;84(2):301-8 - PubMed
  196. J Agric Food Chem. 2006 Nov 1;54(22):8437-43 - PubMed
  197. Int Immunopharmacol. 2012 Jan;12(1):312-4 - PubMed
  198. J Cell Mol Med. 2008 Jun;12(3):1005-22 - PubMed
  199. Mini Rev Med Chem. 2009 Sep;9(10):1159-64 - PubMed
  200. Mol Carcinog. 1993;7(3):139-46 - PubMed
  201. Annu Rev Biochem. 1990;59:395-414 - PubMed
  202. Protein J. 2010 Jul;29(5):314-9 - PubMed
  203. Appl Microbiol Biotechnol. 2010 Aug;87(5):1935-42 - PubMed
  204. J Nat Prod. 1996 Jun;59(6):629-31 - PubMed
  205. Genetika. 2013 May;49(5):609-16 - PubMed
  206. Biophys J. 2002 Aug;83(2):1004-13 - PubMed
  207. J Biochem. 1994 Sep;116(3):482-7 - PubMed
  208. Int J Cancer. 2006 Aug 1;119(3):493-500 - PubMed
  209. J Org Chem. 1996 Jun 14;61(12):4059-4061 - PubMed
  210. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53 - PubMed
  211. Nucleic Acids Res. 2012 Jul;40(Web Server issue):W199-204 - PubMed
  212. Hum Gene Ther. 2009 Apr;20(4):303-13 - PubMed
  213. Arch Immunol Ther Exp (Warsz). 2005 Jan-Feb;53(1):47-60 - PubMed
  214. Protein Expr Purif. 2007 Sep;55(1):175-82 - PubMed
  215. Int J Biochem Cell Biol. 1998 Sep;30(9):1055-62 - PubMed
  216. Appl Environ Microbiol. 2010 Feb;76(3):769-75 - PubMed
  217. Antimicrob Agents Chemother. 2003 Feb;47(2):494-500 - PubMed
  218. J Cell Biochem. 2011 Sep;112(9):2424-34 - PubMed
  219. Biochem Biophys Res Commun. 1996 Feb 15;219(2):555-9 - PubMed
  220. Biomacromolecules. 2011 Nov 14;12(11):3839-43 - PubMed
  221. Virol Sin. 2011 Dec;26(6):357-65 - PubMed
  222. PLoS One. 2011;6(10):e25333 - PubMed
  223. Biomaterials. 2013 May;34(15):3846-57 - PubMed
  224. Int J Cancer. 2003 Apr 20;104(4):512-21 - PubMed

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