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Flake GP, Moore AB, Flagler N, et al. The natural history of uterine leiomyomas: morphometric concordance with concepts of interstitial ischemia and inanosis. Obstet Gynecol Int. 2013;2013:285103doi: 10.1155/2013/285103.
Flake, G. P., Moore, A. B., Flagler, N., Wicker, B., Clayton, N., Kissling, G. E., Robboy, S. J., & Dixon, D. (2013). The natural history of uterine leiomyomas: morphometric concordance with concepts of interstitial ischemia and inanosis. Obstetrics and gynecology international, 2013285103. https://doi.org/10.1155/2013/285103
Flake, Gordon P, et al. "The natural history of uterine leiomyomas: morphometric concordance with concepts of interstitial ischemia and inanosis." Obstetrics and gynecology international vol. 2013 (2013): 285103. doi: https://doi.org/10.1155/2013/285103
Flake GP, Moore AB, Flagler N, Wicker B, Clayton N, Kissling GE, Robboy SJ, Dixon D. The natural history of uterine leiomyomas: morphometric concordance with concepts of interstitial ischemia and inanosis. Obstet Gynecol Int. 2013;2013:285103. doi: 10.1155/2013/285103. Epub 2013 Sep 30. PMID: 24198832; PMCID: PMC3806153.
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Obstet Gynecol Int. 2013;2013:285103. doi: 10.1155/2013/285103. Epub 2013 Sep 30.

The natural history of uterine leiomyomas: morphometric concordance with concepts of interstitial ischemia and inanosis.

Obstetrics and gynecology international

Gordon P Flake, Alicia B Moore, Norris Flagler, Benita Wicker, Natasha Clayton, Grace E Kissling, Stanley J Robboy, Darlene Dixon

Affiliations

  1. Cellular and Molecular Pathology Branch, National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services, Research Triangle Park, NC 27709, USA.

PMID: 24198832 PMCID: PMC3806153 DOI: 10.1155/2013/285103

Abstract

Based upon our morphologic observations, we hypothesize and also provide morphometric evidence for the occurrence of progressive developmental changes in many uterine fibroids, which can be arbitrarily divided into 4 phases. These developmental phases are related to the ongoing production of extracellular collagenous matrix, which eventually exceeds the degree of angiogenesis, resulting in the progressive separation of myocytes from their blood supply and a condition of interstitial ischemia. The consequence of this process of slow ischemia with nutritional and oxygen deprivation is a progressive myocyte atrophy (or inanition), culminating in cell death, a process that we refer to as inanosis. The studies presented here provide quantitative and semiquantitative evidence to support the concept of the declining proliferative activity as the collagenous matrix increases and the microvascular density decreases.

References

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