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Borek C, Higashino S, Loewenstein WR. Intercellular communication and tissue growth : IV. Conductance of membrane junctions of normal and cancerous cells in culture. J Membr Biol. 1969;1(1):274-93doi: 10.1007/BF01869786.
Borek, C., Higashino, S., & Loewenstein, W. R. (1969). Intercellular communication and tissue growth : IV. Conductance of membrane junctions of normal and cancerous cells in culture. The Journal of membrane biology, 1(1), 274-93. https://doi.org/10.1007/BF01869786
Borek, C, et al. "Intercellular communication and tissue growth : IV. Conductance of membrane junctions of normal and cancerous cells in culture." The Journal of membrane biology vol. 1,1 (1969): 274-93. doi: https://doi.org/10.1007/BF01869786
Borek C, Higashino S, Loewenstein WR. Intercellular communication and tissue growth : IV. Conductance of membrane junctions of normal and cancerous cells in culture. J Membr Biol. 1969 Dec;1(1):274-93. doi: 10.1007/BF01869786. PMID: 24174054.
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J Membr Biol. 1969 Dec;1(1):274-93. doi: 10.1007/BF01869786.

Intercellular communication and tissue growth : IV. Conductance of membrane junctions of normal and cancerous cells in culture.

The Journal of membrane biology

C Borek, S Higashino, W R Loewenstein

Affiliations

  1. Cell Physics Laboratory, Department of Physiology, Columbia University, College of Physicians & Surgeons, 10032, New York, New York.

PMID: 24174054 DOI: 10.1007/BF01869786

Abstract

Epithelial cells of normal rat (adult) liver and hamster embryo in tissue culture communicate through membrane junctions: the membrane regions of cell contact are highly ion-permeable. Cancerous counterparts of these cells, cells from Morris' and Reuber's liver tumors and from x-ray-transformed embryo cultures, do not communicate under the same experimental conditions. These cells also fail to communicate with contiguous normal cells. Cancerous fibroblastic cells from a variety of tissues, including cells transformed by virus, x-radiation and chemicals, communicate as well as their normal counterparts; this is so for long- and short-term cell cultures. Communication in some fibroblastic cells is sensitive to components of blood serum: normal and transformed hamster embryo fibroblasts, which communicate when cultured in medium containing fetal calf serum, appear to lose communication in medium containing calf serum; the converse holds for hamster (adult) fibroblasts and 3T3 cells.

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