Display options
Cite
Furtado MR. Inhibition of the permeability response to vasopressin and oxytocin in the toad bladder: Effects of bradykinin, kallidin, eledoisin, and physalaemin. J Membr Biol. 1971;4(1):165-78doi: 10.1007/BF02431969.
Furtado, M. R. (1971). Inhibition of the permeability response to vasopressin and oxytocin in the toad bladder: Effects of bradykinin, kallidin, eledoisin, and physalaemin. The Journal of membrane biology, 4(1), 165-78. https://doi.org/10.1007/BF02431969
Furtado, M R. "Inhibition of the permeability response to vasopressin and oxytocin in the toad bladder: Effects of bradykinin, kallidin, eledoisin, and physalaemin." The Journal of membrane biology vol. 4,1 (1971): 165-78. doi: https://doi.org/10.1007/BF02431969
Furtado MR. Inhibition of the permeability response to vasopressin and oxytocin in the toad bladder: Effects of bradykinin, kallidin, eledoisin, and physalaemin. J Membr Biol. 1971 Dec;4(1):165-78. doi: 10.1007/BF02431969. PMID: 24174237.
Copy Download .nbib Format: NLM
Share it on

J Membr Biol. 1971 Dec;4(1):165-78. doi: 10.1007/BF02431969.

Inhibition of the permeability response to vasopressin and oxytocin in the toad bladder: Effects of bradykinin, kallidin, eledoisin, and physalaemin.

The Journal of membrane biology

M R Furtado

Affiliations

  1. Department of Medicine, Faculty of Medicine, University of São Paulo, Ribeirão Prêto, São Paulo, Brazil.

PMID: 24174237 DOI: 10.1007/BF02431969

Abstract

It has been shown by means of Bentley'sin vitro preparation of the isolated urinary bladder of the toad,Bufo marinus paracnemis Lutz, that bradykinin reversibly inhibited the increase brought about by vasopressin on the permeability to water of the toad bladder. The increased hydro-osmotic response of the bladder to oxytocin was also inhibited by the kinin. The effect on water permeability was observed when bradykinin was added either to the serosal Ringer's solution or to the mucosal solution. The addition of bradykinin alone did not alter the basal osmotic water transfer across the bladder. In this context, bradykinin acted as a competitive antagonist of vasopressin (and oxytocin). Although lacking intrinsic activity, bradykinin exhibited affinity for receptor sites that are also common to the neurohypophysial hormones, causing a parallel shift of the log-dose/response curve for vasopressin without changing the maximal responses. The effects of other kinins (namely kallidin, eledoisin and physalaemin) on the toad bladder were also tested. Each of these drugs alone did not change the basal water flux across the bladder wall. Like bradykinin, these peptides inhibited the increase in water permeability evoked by vasopressin and oxytocin in the bladder. In view of the importance of neurohypophysial hormones and their target tissues to the osmotic homeostasis of amphibians, and the observation of antagonism between the kinins and the pituitary hormones coupled to the abundance of kinins in the amphibian organism, particularly in the skin and urinary bladder, teleological reasoning predicts a physiological role for the kinins, possibly functioning to dampen excesses and oscillations in membrane permeability that could occur in face of a constant and variable secretion of neurohypophysial hormone, thus adding to the homeostatic response of the amphibian organism.

References

  1. Aust J Exp Biol Med Sci. 1967 Feb;45(1):89-95 - PubMed
  2. Arch Biochem Biophys. 1963 Apr;101:56-65 - PubMed
  3. J Clin Invest. 1962 Apr;41:702-9 - PubMed
  4. Jpn J Pharmacol. 1964 Dec;14:468-73 - PubMed
  5. Acta Physiol Lat Am. 1966;16(1):62-5 - PubMed
  6. Circ Res. 1968 Oct;23(4):507-17 - PubMed
  7. J Endocrinol. 1958 Sep;17(3):201-9 - PubMed
  8. Br J Pharmacol Chemother. 1967 Oct;31(2):331-9 - PubMed
  9. Comp Biochem Physiol. 1965 Jan;14:43-52 - PubMed
  10. Ann N Y Acad Sci. 1963 Feb 4;104:77-89 - PubMed
  11. J Gen Physiol. 1963 Jul;46:1171-89 - PubMed
  12. J Gen Physiol. 1968 Sep;52(3):465-81 - PubMed
  13. Fed Proc. 1968 Jan-Feb;27(1):58-62 - PubMed
  14. Arch Int Pharmacodyn Ther. 1954 Sep 15;99(2):193-205 - PubMed
  15. Experientia. 1949 Feb 15;5(2):79-81 - PubMed

Publication Types