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Vijayalashmi R, Ravindranath SM, Jayakumar ND, et al. Kinetics of drug release from a biodegradable local drug delivery system and its effect on Porphyromonas gingivalis isolates: An in vitro study. J Indian Soc Periodontol. 2013;17(4):429-34doi: 10.4103/0972-124X.118311.
Vijayalashmi, R., Ravindranath, S. M., Jayakumar, N. D., Padmalatha, Vargheese, S. H., & Kumaraswamy, K. L. (2013). Kinetics of drug release from a biodegradable local drug delivery system and its effect on Porphyromonas gingivalis isolates: An in vitro study. Journal of Indian Society of Periodontology, 17(4), 429-34. https://doi.org/10.4103/0972-124X.118311
Vijayalashmi, Ranganathan, et al. "Kinetics of drug release from a biodegradable local drug delivery system and its effect on Porphyromonas gingivalis isolates: An in vitro study." Journal of Indian Society of Periodontology vol. 17,4 (2013): 429-34. doi: https://doi.org/10.4103/0972-124X.118311
Vijayalashmi R, Ravindranath SM, Jayakumar ND, Padmalatha, Vargheese SH, Kumaraswamy KL. Kinetics of drug release from a biodegradable local drug delivery system and its effect on Porphyromonas gingivalis isolates: An in vitro study. J Indian Soc Periodontol. 2013 Jul;17(4):429-34. doi: 10.4103/0972-124X.118311. PMID: 24174719; PMCID: PMC3800402.
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J Indian Soc Periodontol. 2013 Jul;17(4):429-34. doi: 10.4103/0972-124X.118311.

Kinetics of drug release from a biodegradable local drug delivery system and its effect on Porphyromonas gingivalis isolates: An in vitro study.

Journal of Indian Society of Periodontology

Ranganathan Vijayalashmi, Sabitha Manhalore Ravindranath, Nadathur Doraiswamy Jayakumar, Padmalatha, Sheeja H Vargheese, Kikkeri Laxminarayana Kumaraswamy

Affiliations

  1. Department of Periodontics, Farooqia Dental College and Hospital, Mysore, India.

PMID: 24174719 PMCID: PMC3800402 DOI: 10.4103/0972-124X.118311

Abstract

BACKGROUND: Conventional anti-microbial therapy largely consisted of systemic administration of various drugs effective against periodontal pathogens, but fraught with several problems. Based on the concept of local drug delivery a bioresorbable device made of pure fibrillar collagen has been developed. The aim of this study was to study the release of Tetracycline from this collagen fiber (Type I collagen) impregnated with Tetracycline and its antibacterial activity against Porphyromonas gingivalis.

MATERIALS AND METHODS: Porphyromonas gingivalis was isolated from plaque samples of chronic periodontitis patients by using a CO2 incubator. DNA isolation was done followed by polymerase chain reaction (PCR) amplification to confirm the presence of bacteria. The release pattern of Tetracycline was assessed for a period of 10 days in water (group I) and Serum inoculated with Porphyromonas gingivalis (group II).

RESULTS: A significant presence of Tetracycline on all days in Group I and group II and the zone of inhibition was also present in both groups with a steady decline from day 1 to day 10.

CONCLUSION: Since the results were well within the therapeutic concentration of drug required to inhibit the growth of gram -ve bacteria (Porphyromonas gingivalis), this bioresorbable Tetracycline fiber has the potential for clinical application.

Keywords: Collagen fiber; Porphyromonas gingivalis; polymerase chain reaction; tetracycline

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