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Cotlarciuc I, Khan MS, Maheshwari A, et al. Bio-repository of DNA in stroke: a study protocol of three ancestral populations. JRSM Cardiovasc Dis. 2012;1(4)doi: 10.1258/cvd.2012.012019.
Cotlarciuc, I., Khan, M. S., Maheshwari, A., Yadav, S., Khan, F. Y., Al-Hail, H., de Silva, R., Gorthi, S. P., Gupta, S., Sharma, S. R., Sylaja, P. N., Prasad, K., & Sharma, P. (2012). Bio-repository of DNA in stroke: a study protocol of three ancestral populations. JRSM cardiovascular disease, 1(4), . https://doi.org/10.1258/cvd.2012.012019
Cotlarciuc, Ioana, et al. "Bio-repository of DNA in stroke: a study protocol of three ancestral populations." JRSM cardiovascular disease vol. 1,4 (2012). doi: https://doi.org/10.1258/cvd.2012.012019
Cotlarciuc I, Khan MS, Maheshwari A, Yadav S, Khan FY, Al-Hail H, de Silva R, Gorthi SP, Gupta S, Sharma SR, Sylaja PN, Prasad K, Sharma P. Bio-repository of DNA in stroke: a study protocol of three ancestral populations. JRSM Cardiovasc Dis. 2012 Jul 30;1(4). doi: 10.1258/cvd.2012.012019. PMID: 24175068; PMCID: PMC3738328.
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JRSM Cardiovasc Dis. 2012 Jul 30;1(4). doi: 10.1258/cvd.2012.012019.

Bio-repository of DNA in stroke: a study protocol of three ancestral populations.

JRSM cardiovascular disease

Ioana Cotlarciuc, Muhammad Saleem Khan, Ankita Maheshwari, Sunaina Yadav, Fahmi Yousif Khan, H Al-Hail, Ranil de Silva, S P Gorthi, Salil Gupta, Shri Ram Sharma, P N Sylaja, Kameshwar Prasad, Pankaj Sharma

Affiliations

  1. Imperial College Cerebrovascular Research Unit (ICCRU) , Imperial College London , London , UK.

PMID: 24175068 PMCID: PMC3738328 DOI: 10.1258/cvd.2012.012019

Abstract

Stroke is a leading cause of death and disability in the world. Identifying the genes underlying stroke risk may help us to improve our understanding of the mechanisms that cause stroke and also identify novel therapeutic targets. To have sufficient power to disentangle the genetic component of stroke, large-scale highly phenotyped DNA repositories are necessary. The BRAINS (Bio-repository of DNA in stroke) study aims to recruit subjects with all subtypes of stroke as well as controls from UK, India, Sri Lanka and Qatar. BRAINS-UK will include 1500 stroke patients of European ancestry as well as British South Asians. BRAINS-South Asia aims to recruit 3000 stroke subjects and 3000 controls from across India and Sri Lanka. BRAINS-Middle East aims to enrol 1500 stroke patients from Qatar. The controls for BRAINS-Middle East will be recruited from a population-based Qatari Biobank. With the addition of new recruitment centres in India and Qatar, we present an updated version of the BRAINS study protocol. This is the first international DNA biobank for stroke patients and controls from the Middle East. By investigating the influence of genetic factors on stroke risk in European, South Asian and Middle Eastern populations, BRAINS has the potential to improve our understanding of genetic differences between these groups and may lead to new population-specific therapeutic targets.

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