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Edwardson JA, Candy JM. Aluminium and the pathogenesis of senile plaques: studies in Alzheimer's disease and chronic renal failure. Environ Geochem Health. 1990;12(1):94-6doi: 10.1007/BF01734057.
Edwardson, J. A., & Candy, J. M. (1990). Aluminium and the pathogenesis of senile plaques: studies in Alzheimer's disease and chronic renal failure. Environmental geochemistry and health, 12(1), 94-6. https://doi.org/10.1007/BF01734057
Edwardson, J A, and Candy, J M. "Aluminium and the pathogenesis of senile plaques: studies in Alzheimer's disease and chronic renal failure." Environmental geochemistry and health vol. 12,1 (1990): 94-6. doi: https://doi.org/10.1007/BF01734057
Edwardson JA, Candy JM. Aluminium and the pathogenesis of senile plaques: studies in Alzheimer's disease and chronic renal failure. Environ Geochem Health. 1990 Mar;12(1):94-6. doi: 10.1007/BF01734057. PMID: 24202574.
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Environ Geochem Health. 1990 Mar;12(1):94-6. doi: 10.1007/BF01734057.

Aluminium and the pathogenesis of senile plaques: studies in Alzheimer's disease and chronic renal failure.

Environmental geochemistry and health

J A Edwardson, J M Candy

Affiliations

  1. MRC Neurochemical Pathology Unit, Newcastle General Hospital, NE4 6BE, Newcastle upon Tyne, UK.

PMID: 24202574 DOI: 10.1007/BF01734057

Abstract

Aluminium and silicon are co-localised as aluminosilicate at the centre of the senile plaque core. These focal deposits appear to be a consistent and specific feature associated with A4 amyloid fibrils in the plaque core and are not associated with other types of amyloidosis. A pathogenic role for AI and Si is suggested by the finding of A4 amyloid deposits, immature senile plaques and an abnormal content and distribution of these elements in the brains of patients (<55 years) with chronic renal failure. Evidence suggests that AI uptake and distribution within the brain is mediated by transferrin. The distribution of transferrin receptors may account for the vulnerability of regions such as the hippocampus and cortex which are selectively involved in Alzheimer's disease.

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