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Su S, Duan J, Cui W, et al. Network-based biomarkers for cold coagulation blood stasis syndrome and the therapeutic effects of shaofu zhuyu decoction in rats. Evid Based Complement Alternat Med. 2013;2013:901943doi: 10.1155/2013/901943.
Su, S., Duan, J., Cui, W., Shang, E., Liu, P., Bai, G., Guo, S., Qian, D., & Tang, Y. (2013). Network-based biomarkers for cold coagulation blood stasis syndrome and the therapeutic effects of shaofu zhuyu decoction in rats. Evidence-based complementary and alternative medicine : eCAM, 2013901943. https://doi.org/10.1155/2013/901943
Su, Shulan, et al. "Network-based biomarkers for cold coagulation blood stasis syndrome and the therapeutic effects of shaofu zhuyu decoction in rats." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 901943. doi: https://doi.org/10.1155/2013/901943
Su S, Duan J, Cui W, Shang E, Liu P, Bai G, Guo S, Qian D, Tang Y. Network-based biomarkers for cold coagulation blood stasis syndrome and the therapeutic effects of shaofu zhuyu decoction in rats. Evid Based Complement Alternat Med. 2013;2013:901943. doi: 10.1155/2013/901943. Epub 2013 Oct 21. PMID: 24288569; PMCID: PMC3818846.
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Evid Based Complement Alternat Med. 2013;2013:901943. doi: 10.1155/2013/901943. Epub 2013 Oct 21.

Network-based biomarkers for cold coagulation blood stasis syndrome and the therapeutic effects of shaofu zhuyu decoction in rats.

Evidence-based complementary and alternative medicine : eCAM

Shulan Su, Jinao Duan, Wenxia Cui, Erxing Shang, Pei Liu, Gang Bai, Sheng Guo, Dawei Qian, Yuping Tang

Affiliations

  1. Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210046, China.

PMID: 24288569 PMCID: PMC3818846 DOI: 10.1155/2013/901943

Abstract

In this study, the reverse docking methodology was applied to predict the action targets and pathways of Shaofu Zhuyu decoction (SFZYD) bioactive ingredients. Furthermore, Traditional Chinese Medicine (TCM) cold coagulation blood stasis (CCBS) syndrome was induced in female Sprague-Dawley rats with an ice-water bath and epinephrine, and SFZYD was used to treat CCBS syndrome. A metabolomic approach was used to evaluate changes in the metabolic profiles and to analyze the pharmacological mechanism of SFZYD actions. Twenty-three potential protein targets and 15 pathways were discovered, respectively; among these, pathways are associated with inflammation and immunological stress, hormone metabolism, coagulation function, and glycometabolism. There were also changes in the levels of endogenous metabolites of LysoPCs and glucuronides. Twenty endogenous metabolites were identified. Furthermore, the relative quantities of 6 endogenous metabolites in the plasma and 5 in the urine were significantly affected by SFZYD (P < 0.05). The pharmacological mechanism of SFZYD was partially associated with glycerophospholipid metabolism and pentose and glucuronate interconversions. In conclusion, our findings demonstrated that TCM CCBS pattern induced by ice water and epinephrine was complex and related to multiple metabolic pathways. SFZYD did regulate the TCM CCBS by multitargets, and biomarkers and SFZYD should be used for the clinical treatment of CCBS syndrome.

References

  1. Nature. 2011 Aug 31;477(7362):54-60 - PubMed
  2. Evid Based Complement Alternat Med. 2012;2012:102641 - PubMed
  3. Mol Biosyst. 2010 Apr;6(4):613-9 - PubMed
  4. BMC Syst Biol. 2011 Jun 20;5 Suppl 1:S10 - PubMed
  5. J Proteomics. 2012 Feb 2;75(4):1411-27 - PubMed
  6. Zhong Xi Yi Jie He Xue Bao. 2008 Apr;6(4):355-60 - PubMed
  7. BMC Bioinformatics. 2010 Dec 14;11 Suppl 11:S6 - PubMed
  8. J Proteome Res. 2012 Feb 3;11(2):1284-301 - PubMed
  9. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14458-62 - PubMed
  10. Evid Based Complement Alternat Med. 2013;2013:456747 - PubMed
  11. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Feb 1;878(3-4):355-62 - PubMed
  12. Adv Prostaglandin Thromboxane Res. 1980;8:1443-7 - PubMed
  13. IET Syst Biol. 2007 Jan;1(1):51-60 - PubMed
  14. Food Chem Toxicol. 2009 Aug;47(8):1797-802 - PubMed
  15. Evid Based Complement Alternat Med. 2012;2012:149762 - PubMed
  16. Exp Mol Med. 2009 May 31;41(5):334-40 - PubMed
  17. Hypertension. 1998 Feb;31(2):603-7 - PubMed
  18. Clin Hemorheol Microcirc. 2000;23(2-4):127-31 - PubMed
  19. J Proteome Res. 2013 Feb 1;12(2):852-65 - PubMed
  20. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10001-5 - PubMed
  21. Anal Chem. 2012 Jan 3;84(1):428-39 - PubMed
  22. Psychosom Med. 1988 Jul-Aug;50(4):381-93 - PubMed
  23. J Proteome Res. 2007 Feb;6(2):443-58 - PubMed
  24. Am J Chin Med. 2013;41(3):697-715 - PubMed
  25. Nat Rev Drug Discov. 2003 Aug;2(8):668-76 - PubMed
  26. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):17017-22 - PubMed
  27. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15163-8 - PubMed
  28. J Mol Cell Cardiol. 2008 Sep;45(3):437-45 - PubMed
  29. J Endocrinol. 1999 Jan;160(1):1-12 - PubMed
  30. Chin J Nat Med. 2013 Mar;11(2):110-20 - PubMed
  31. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007 Dec;29(6):712-8 - PubMed
  32. Anal Chem. 2012 Mar 20;84(6):2995-3002 - PubMed
  33. Science. 2003 May 2;300(5620):740-1 - PubMed

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