Display options
Cite
Hirano Y, Saitoe M. Hunger and memory; CRTC coordinates long-term memory with the physiological state, hunger. Commun Integr Biol. 2013;6(5):e25152doi: 10.4161/cib.25152.
Hirano, Y., & Saitoe, M. (2013). Hunger and memory; CRTC coordinates long-term memory with the physiological state, hunger. Communicative & integrative biology, 6(5), e25152. https://doi.org/10.4161/cib.25152
Hirano, Yukinori, and Saitoe, Minoru. "Hunger and memory; CRTC coordinates long-term memory with the physiological state, hunger." Communicative & integrative biology vol. 6,5 (2013): e25152. doi: https://doi.org/10.4161/cib.25152
Hirano Y, Saitoe M. Hunger and memory; CRTC coordinates long-term memory with the physiological state, hunger. Commun Integr Biol. 2013 Sep 01;6(5):e25152. doi: 10.4161/cib.25152. Epub 2013 Jun 04. PMID: 24265850; PMCID: PMC3829949.
Copy Download .nbib Format: NLM
Share it on

Commun Integr Biol. 2013 Sep 01;6(5):e25152. doi: 10.4161/cib.25152. Epub 2013 Jun 04.

Hunger and memory; CRTC coordinates long-term memory with the physiological state, hunger.

Communicative & integrative biology

Yukinori Hirano, Minoru Saitoe

Affiliations

  1. Department of Sensory and Motor Systems; Tokyo Metropolitan Institute of Medical Science; Setagaya, Tokyo, Japan ; Japan Science and Technology Agency; PRESTO; Saitama, Japan.

PMID: 24265850 PMCID: PMC3829949 DOI: 10.4161/cib.25152

Abstract

Animals form and store memory, which advantageously adjusts their behavior later on. Although the growing body of evidences suggests the basic mechanisms of memory, it is not clear whether and in which physiological state memory functions can be altered. Here we discuss our recent study that mild fasting facilitates long-term memory (LTM) formation in Drosophila.(1) Canonical LTM in flies is induced by multiple training with rest intervals, and is mediated by a transcription factor, CREB and its binding protein, CBP. However, fasting allows LTM formation (fLTM) only by single-cycle training, in a manner dependent on another CREB binding protein, CRTC. Although it has been controversial, we are convinced that gene expression in a specific neural structure, called mushroom body (MB), is required for LTMs. We also showed data suggesting that reduced insulin signaling during fasting activates CRTC, thereby inducing fLTM formation. These data provides the conceptual advance that flies adapt their mechanisms for LTM formation according to their internal condition, hunger state. Due to limited food resources in the wild, fLTM could be one of the major form of LTM in natural environment. Furthermore, our data also indicate a novel conception that improvement of memory deficit might be achieved by activation of CRTC.

Keywords: CBP; CREB; CRTC; Drosophila; insulin signaling; long-term memory

References

  1. Genetics. 2004 May;167(1):311-23 - PubMed
  2. Neuron. 2012 Apr 26;74(2):246-60 - PubMed
  3. Science. 2013 Jan 25;339(6118):440-2 - PubMed
  4. Science. 2012 Feb 10;335(6069):678-85 - PubMed
  5. J Neurosci. 2008 Mar 19;28(12):3103-13 - PubMed
  6. Science. 2013 Jan 25;339(6118):443-6 - PubMed
  7. Cell. 1994 Oct 7;79(1):35-47 - PubMed
  8. Nat Rev Mol Cell Biol. 2011 Mar;12(3):141-51 - PubMed
  9. Cell. 1994 Oct 7;79(1):49-58 - PubMed
  10. Nature. 2007 Sep 20;449(7160):366-9 - PubMed
  11. Cell Metab. 2008 May;7(5):434-44 - PubMed
  12. Neuron. 2006 Dec 7;52(5):845-55 - PubMed

Publication Types