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Decuypere JP, Paudel RC, Parys J, et al. Intracellular Ca(2+) signaling: A novel player in the canonical mTOR-controlled autophagy pathway. Commun Integr Biol. 2013;6(5):e25429doi: 10.4161/cib.25429.
Decuypere, J. P., Paudel, R. C., Parys, J., & Bultynck, G. (2013). Intracellular Ca(2+) signaling: A novel player in the canonical mTOR-controlled autophagy pathway. Communicative & integrative biology, 6(5), e25429. https://doi.org/10.4161/cib.25429
Decuypere, Jean-Paul, et al. "Intracellular Ca(2+) signaling: A novel player in the canonical mTOR-controlled autophagy pathway." Communicative & integrative biology vol. 6,5 (2013): e25429. doi: https://doi.org/10.4161/cib.25429
Decuypere JP, Paudel RC, Parys J, Bultynck G. Intracellular Ca(2+) signaling: A novel player in the canonical mTOR-controlled autophagy pathway. Commun Integr Biol. 2013 Sep 01;6(5):e25429. doi: 10.4161/cib.25429. Epub 2013 Jun 25. PMID: 24265855; PMCID: PMC3829968.
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Commun Integr Biol. 2013 Sep 01;6(5):e25429. doi: 10.4161/cib.25429. Epub 2013 Jun 25.

Intracellular Ca(2+) signaling: A novel player in the canonical mTOR-controlled autophagy pathway.

Communicative & integrative biology

Jean-Paul Decuypere, Ram Chandra Paudel, Jan Parys, Geert Bultynck

Affiliations

  1. Laboratory of Molecular and Cellular Signaling; Department of Cellular and Molecular Medicine; KU Leuven; Leuven, Belgium ; Current affiliation: Laboratory of Abdominal Transplant Surgery; Department of Microbiology and Immunology; University Hospitals Leuven; KU Leuven; Leuven, Belgium.

PMID: 24265855 PMCID: PMC3829968 DOI: 10.4161/cib.25429

Abstract

Functional intracellular Ca(2+) signaling is essential for the upregulation of the canonical mTOR-controlled autophagy pathway triggered by rapamycin or by nutrient deprivation. Moreover, modifications in the Ca(2+)-signaling machinery coincide with autophagy stimulation. This results in enhanced intracellular Ca(2+) signaling essential for driving the autophagy process. Yet, the mechanisms upstream (the players causing the changes in Ca(2+) signaling) and downstream (the targets of the altered Ca(2+) signals) of this Ca(2+)-dependent autophagy pathway remain elusive. Here, we speculate about these mechanisms based on our current knowledge.

Keywords: Beclin 1; Ca2+ signaling; autophagosomes; autophagy; endoplasmic reticulum; inositol 1,4,5-trisphosphate receptor; mTOR

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