Display options
Cite
Lee EK, Jun JK, Choi UY, et al. Nasopharyngeal Carriage Rate and Serotypes of Streptococcus pneumoniae and Antimicrobial Susceptibility in Healthy Korean Children Younger than 5 Years Old: Focus on Influence of Pneumococcal Conjugate Vaccination. Infect Chemother. 2013;45(1):76-84doi: 10.3947/ic.2013.45.1.76.
Lee, E. K., Jun, J. K., Choi, U. Y., Kwon, H. J., Kim, K. H., & Kang, J. H. (2013). Nasopharyngeal Carriage Rate and Serotypes of Streptococcus pneumoniae and Antimicrobial Susceptibility in Healthy Korean Children Younger than 5 Years Old: Focus on Influence of Pneumococcal Conjugate Vaccination. Infection & chemotherapy, 45(1), 76-84. https://doi.org/10.3947/ic.2013.45.1.76
Lee, Eu Kyoung, et al. "Nasopharyngeal Carriage Rate and Serotypes of Streptococcus pneumoniae and Antimicrobial Susceptibility in Healthy Korean Children Younger than 5 Years Old: Focus on Influence of Pneumococcal Conjugate Vaccination." Infection & chemotherapy vol. 45,1 (2013): 76-84. doi: https://doi.org/10.3947/ic.2013.45.1.76
Lee EK, Jun JK, Choi UY, Kwon HJ, Kim KH, Kang JH. Nasopharyngeal Carriage Rate and Serotypes of Streptococcus pneumoniae and Antimicrobial Susceptibility in Healthy Korean Children Younger than 5 Years Old: Focus on Influence of Pneumococcal Conjugate Vaccination. Infect Chemother. 2013 Mar;45(1):76-84. doi: 10.3947/ic.2013.45.1.76. Epub 2013 Mar 29. PMID: 24265953; PMCID: PMC3780942.
Copy Download .nbib Format: NLM
Share it on

Infect Chemother. 2013 Mar;45(1):76-84. doi: 10.3947/ic.2013.45.1.76. Epub 2013 Mar 29.

Nasopharyngeal Carriage Rate and Serotypes of Streptococcus pneumoniae and Antimicrobial Susceptibility in Healthy Korean Children Younger than 5 Years Old: Focus on Influence of Pneumococcal Conjugate Vaccination.

Infection & chemotherapy

Eu Kyoung Lee, Ja Kyung Jun, Ui Yoon Choi, Hyo-Jin Kwon, Kyung-Hyo Kim, Jin Han Kang

Affiliations

  1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

PMID: 24265953 PMCID: PMC3780942 DOI: 10.3947/ic.2013.45.1.76

Abstract

BACKGROUND: Even after pneumococcal vaccination introduction, Streptococcus pneumoniae (pneumoccocus) is still an important cause of respiratory and invasive severe infection. Pneumococcus is resided in nasal mucosa and local or systemic infection begins with the nasal mucosa damage. We studied the indirect effect of pneumococcal conjugate vaccine (PCV) on pneumococcal nasopharyngeal carriage rates, serotypes and antimicrobial susceptibility between vaccinate and non-vaccinated children.

MATERIALS AND METHODS: From January 2010 to October 2010, 379 healthy children under 5 years old from three university hospitals were recruited. Fully vaccinated children over 3 time doses of PCV and children with no vaccination history of PCV were enrolled, and nasopharyngeal aspirations were obtained from these children. Serotypes using multibead serotyping assay with multiplex PCR and antimicrobial susceptibility was analyzed. Antimicrobial susceptibilities were determined by the CLIS guideline.

RESULTS: Two hundred seventy six children were received pneumococcal vaccination while 103 were not. 137 pneumococci were isolated from nasopharyngeal aspiration specimens. Nasal carriage rate was significantly low in vaccinated group (P-value; 0.001). Nasopharyngeal carriage rate was 28.6% (79/276) in vaccinate group and 56.3% (58/103) in non-vaccinated group. Among those vaccinated group, 13.0% (36/276) of the serotypes were vaccine or vaccine related type with the most common type 19F. In contrast, 31.1% (32/103) of the serotypes in non vaccinated group were vaccine or vaccine related type with the most common type 6A. The resistant rate of penicillin was 90.5%. For antimicrobial susceptibility, amoxicillin and amoxicillin/clavulanate showed high susceptibility (73.0%), but 19F and 19A serotypes were all resistant against amoxicillin.

CONCLUSIONS: High nasopharyngeal carriage rate in non vaccinated group corresponded to the result of past study. However, 19F and 19A still came up as problematic serotypes with a high carriage rate and antimicrobial resistance in both vaccinated and non vaccinated groups. Also, this study showed that the resistance rate of primary oral antimicrobial agents was increased in compared to past. For solving these problems, the selective antimicrobial use with establishment of high dose amoxicillin/clavulanate regimen and active PCV immunization should be needed. Furthermore, pneumococcal carriage and serotype study concerning with antimicrobial susceptibility should be conducted in the future in 10 or 13-valent PCV received children.

Keywords: Antimicrobial resistance; Oral antimicrobial; Pneumococcal conjugate vaccine; Serotype; Streptococcus pneumoniae

References

  1. J Clin Microbiol. 2012 Mar;50(3):818-22 - PubMed
  2. J Korean Med Sci. 2011 Feb;26(2):184-90 - PubMed
  3. Postgrad Med. 2003 Jan;113(1):42-4, 47-8, 52-4 - PubMed
  4. Antimicrob Agents Chemother. 1996 May;40(5):1208-13 - PubMed
  5. J Chemother. 1997 May;9 Suppl 3:38-44 - PubMed
  6. J Infect Dis. 1996 Dec;174(6):1352-5 - PubMed
  7. J Chemother. 1999 Feb;11 Suppl 1:5-21 - PubMed
  8. Pediatrics. 2009 Jul;124(1):e1-11 - PubMed
  9. Clin Infect Dis. 1998 Jan;26(1):1-10; quiz 11-2 - PubMed
  10. Clin Microbiol Infect. 2002;8 Suppl 3:21-32; discussion 33-5 - PubMed
  11. Microb Drug Resist. 1998 Fall;4(3):209-17 - PubMed
  12. Microbes Infect. 2000 Dec;2(15):1855-64 - PubMed
  13. J Med Microbiol. 2008 Feb;57(Pt 2):171-178 - PubMed
  14. Clin Microbiol Infect. 2001 Nov;7(11):589-96 - PubMed
  15. Pediatr Infect Dis J. 1993 Oct;12(10):824-30 - PubMed
  16. J Infect Dis. 1988 Nov;158(5):956-64 - PubMed
  17. J Infect Dis. 2009 Nov 1;200(9):1375-80 - PubMed
  18. Antimicrob Agents Chemother. 2000 Aug;44(8):2193-6 - PubMed
  19. J Infect Dis. 1980 Dec;142(6):923-33 - PubMed
  20. Jpn J Antibiot. 2010 Feb;63(1):11-7 - PubMed
  21. Microbiology (Reading). 2010 Feb;156(Pt 2):555-560 - PubMed
  22. Epidemiol Rev. 1996;18(1):10-28 - PubMed

Publication Types