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Visweswara Rao P, Madhavi K, Dhananjaya Naidu M, et al. Rhinacanthus nasutus Improves the Levels of Liver Carbohydrate, Protein, Glycogen, and Liver Markers in Streptozotocin-Induced Diabetic Rats. Evid Based Complement Alternat Med. 2013;2013:102901doi: 10.1155/2013/102901.
Visweswara Rao, P., Madhavi, K., Dhananjaya Naidu, M., & Gan, S. H. (2013). Rhinacanthus nasutus Improves the Levels of Liver Carbohydrate, Protein, Glycogen, and Liver Markers in Streptozotocin-Induced Diabetic Rats. Evidence-based complementary and alternative medicine : eCAM, 2013102901. https://doi.org/10.1155/2013/102901
Visweswara Rao, Pasupuleti, et al. "Rhinacanthus nasutus Improves the Levels of Liver Carbohydrate, Protein, Glycogen, and Liver Markers in Streptozotocin-Induced Diabetic Rats." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 102901. doi: https://doi.org/10.1155/2013/102901
Visweswara Rao P, Madhavi K, Dhananjaya Naidu M, Gan SH. Rhinacanthus nasutus Improves the Levels of Liver Carbohydrate, Protein, Glycogen, and Liver Markers in Streptozotocin-Induced Diabetic Rats. Evid Based Complement Alternat Med. 2013;2013:102901. doi: 10.1155/2013/102901. Epub 2013 Sep 24. PMID: 24204387; PMCID: PMC3800587.
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Evid Based Complement Alternat Med. 2013;2013:102901. doi: 10.1155/2013/102901. Epub 2013 Sep 24.

Rhinacanthus nasutus Improves the Levels of Liver Carbohydrate, Protein, Glycogen, and Liver Markers in Streptozotocin-Induced Diabetic Rats.

Evidence-based complementary and alternative medicine : eCAM

Pasupuleti Visweswara Rao, K Madhavi, M Dhananjaya Naidu, Siew Hua Gan

Affiliations

  1. Department of Biotechnology, Sri Venkateswara University, Tirupati, Andhra Pradesh 517502, India ; Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, 16150 Kubang Kerian, Malaysia.

PMID: 24204387 PMCID: PMC3800587 DOI: 10.1155/2013/102901

Abstract

The present study was designed to investigate the total carbohydrate, total protein, and glycogen levels in the liver and to measure functional liver markers such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in streptozotocin-(STZ-) induced diabetic rats after treatment with methanolic extract of Rhinacanthus nasutus (R. nasutus). The methanolic extract of R. nasutus was orally administered at 200 mg/kg/day while glibenclamide was administered at 50 mg/kg/day. All animals were treated for 30 days before being sacrificed. The amounts of carbohydrate, glycogen, proteins, and liver markers (AST and ALT) were measured in the liver tissue of the experimental animals. The levels of carbohydrate, glycogen, and proteins were significantly reduced in the diabetic rats but were augmented considerably after 30 days of R. nasutus treatment. The elevated AST and ALT levels in diabetic rats showed a significant decline after treatment with R. nasutus for 30 days. These results show that the administration of R. nasutus ameliorates the altered levels of carbohydrate, glycogen, proteins, and AST and ALT observed in diabetic rats and indicate that R. nasutus restores overall metabolism and liver function in experimental diabetic rats. In conclusion, the outcomes of the present study support the traditional belief that R. nasutus could ameliorate the diabetic state.

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