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Chihara D, Ito H, Matsuda T, et al. Association between decreasing trend in the mortality of adult T-cell leukemia/lymphoma and allogeneic hematopoietic stem cell transplants in Japan: analysis of Japanese vital statistics and Japan Society for Hematopoietic Cell Transplantation (JSHCT). Blood Cancer J. 2013;3:e159doi: 10.1038/bcj.2013.57.
Chihara, D., Ito, H., Matsuda, T., Katanoda, K., Shibata, A., Taniguchi, S., Utsunomiya, A., Sobue, T., & Matsuo, K. (2013). Association between decreasing trend in the mortality of adult T-cell leukemia/lymphoma and allogeneic hematopoietic stem cell transplants in Japan: analysis of Japanese vital statistics and Japan Society for Hematopoietic Cell Transplantation (JSHCT). Blood cancer journal, 3e159. https://doi.org/10.1038/bcj.2013.57
Chihara, D, et al. "Association between decreasing trend in the mortality of adult T-cell leukemia/lymphoma and allogeneic hematopoietic stem cell transplants in Japan: analysis of Japanese vital statistics and Japan Society for Hematopoietic Cell Transplantation (JSHCT)." Blood cancer journal vol. 3 (2013): e159. doi: https://doi.org/10.1038/bcj.2013.57
Chihara D, Ito H, Matsuda T, Katanoda K, Shibata A, Taniguchi S, Utsunomiya A, Sobue T, Matsuo K. Association between decreasing trend in the mortality of adult T-cell leukemia/lymphoma and allogeneic hematopoietic stem cell transplants in Japan: analysis of Japanese vital statistics and Japan Society for Hematopoietic Cell Transplantation (JSHCT). Blood Cancer J. 2013 Nov 15;3:e159. doi: 10.1038/bcj.2013.57. PMID: 24241399; PMCID: PMC3880440.
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Blood Cancer J. 2013 Nov 15;3:e159. doi: 10.1038/bcj.2013.57.

Association between decreasing trend in the mortality of adult T-cell leukemia/lymphoma and allogeneic hematopoietic stem cell transplants in Japan: analysis of Japanese vital statistics and Japan Society for Hematopoietic Cell Transplantation (JSHCT).

Blood cancer journal

D Chihara, H Ito, T Matsuda, K Katanoda, A Shibata, S Taniguchi, A Utsunomiya, T Sobue, K Matsuo

Affiliations

  1. Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.

PMID: 24241399 PMCID: PMC3880440 DOI: 10.1038/bcj.2013.57

Abstract

Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell neoplasm with a very poor outcome. However, several studies have shown a progress in the treatment. To evaluate the effect of the progress in the treatment of ATLL in a whole patient population, we used vital statistics data and estimated age-adjusted mortality and trends in the mortality from 1995 to 2009. Since allogeneic hematopoietic stem-cell transplantation (allo-HSCT) has been introduced as a modality with curative potential during study period, we also evaluated the association of the annual number of allo-HSCT and the trend of the mortality of ATLL. Endemic (Kyushu) and non-endemic areas (others) were evaluated separately. Significance in the trend of mortality was evaluated by joinpoint regression analysis. During the study period, a total of 14 932 patients died of ATLL in Japan, and mortality decreased significantly in both areas (annual percent change (95% confidence interval (CI)): Kyushu, -3.1% (-4.3, -1.9); others, -3.4% (-5.3, -1.5)). This decreasing trend in mortality seems to be associated with an increase in the number of allo-HSCTs (Kyushu, R-squared=0.70, P=0.003; and others, R-squared=0.55, P=0.058). This study reveals that the mortality of ATLL is now significantly decreasing in Japan and this decreasing trend might be associated with allo-HSCT.

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