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Ellis BE, Remmen S, Goeree G. Interactions between parallel pathways during biosynthesis of rosmarinic acid in cell suspension cultures of Coleus blumei. Planta. 1979;147(2):163-7doi: 10.1007/BF00389519.
Ellis, B. E., Remmen, S., & Goeree, G. (1979). Interactions between parallel pathways during biosynthesis of rosmarinic acid in cell suspension cultures of Coleus blumei. Planta, 147(2), 163-7. https://doi.org/10.1007/BF00389519
Ellis, B E, et al. "Interactions between parallel pathways during biosynthesis of rosmarinic acid in cell suspension cultures of Coleus blumei." Planta vol. 147,2 (1979): 163-7. doi: https://doi.org/10.1007/BF00389519
Ellis BE, Remmen S, Goeree G. Interactions between parallel pathways during biosynthesis of rosmarinic acid in cell suspension cultures of Coleus blumei. Planta. 1979 Dec;147(2):163-7. doi: 10.1007/BF00389519. PMID: 24310974.
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Planta. 1979 Dec;147(2):163-7. doi: 10.1007/BF00389519.

Interactions between parallel pathways during biosynthesis of rosmarinic acid in cell suspension cultures of Coleus blumei.

Planta

B E Ellis, S Remmen, G Goeree

Affiliations

  1. Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, N1G 2W1, Guelph, Ont, Canada.

PMID: 24310974 DOI: 10.1007/BF00389519

Abstract

Phenylalanine ammonia-lyase from an "over-producer" strain of Coleus blumei Benth. cell cultures accumulating high levels of rosmarinic acid (RA) has been shown to possess no special feed-back sensitivity to RA or its precursors. No tyrosine-3-hydroxylase activity could be detected in culture extracts and no specific inhibitors of tyrosine incorporation into RA were found. L-α-aminooxy-β-phenyl propionic acid, however, was effective in specifically blocking phenylalanine incorporation. This block also led to an accumulation of label from tyrosine in 4-hydroxyphenyllactic acid rather than in 3,4-dihydroxyphenylalanine (DOPA) or 3,4-dihydroxyphenyllactic acid. These observations require a re-evaluation of the possible role of DOPA as a major biogenic precursor to RA.

References

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