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Bautista AF, Akca O. Hypercapnia: is it protective in lung injury?. Med Gas Res. 2013;3(1):23doi: 10.1186/2045-9912-3-23.
Bautista, A. F., & Akca, O. (2013). Hypercapnia: is it protective in lung injury?. Medical gas research, 3(1), 23. https://doi.org/10.1186/2045-9912-3-23
Bautista, Alexander F, and Akca, Ozan. "Hypercapnia: is it protective in lung injury?." Medical gas research vol. 3,1 (2013): 23. doi: https://doi.org/10.1186/2045-9912-3-23
Bautista AF, Akca O. Hypercapnia: is it protective in lung injury?. Med Gas Res. 2013 Nov 11;3(1):23. doi: 10.1186/2045-9912-3-23. PMID: 24209944; PMCID: PMC3833649.
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Med Gas Res. 2013 Nov 11;3(1):23. doi: 10.1186/2045-9912-3-23.

Hypercapnia: is it protective in lung injury?.

Medical gas research

Alexander F Bautista, Ozan Akca

Affiliations

  1. Department of Anesthesiology & Perioperative Medicine, University of Louisville, Louisville, KY 40202, USA. [email protected].

PMID: 24209944 PMCID: PMC3833649 DOI: 10.1186/2045-9912-3-23

Abstract

Hypercapnic acidosis has been regarded as a tolerated side effect of protective lung ventilation strategies. Various in vivo and ex vivo animal studies have shown beneficial effects in acute lung injury setting, but some recent work raised concerns about its anti-inflammatory properties. This mini-review article aims to expand the potential clinical spectrum of hypercapnic acidosis in critically ill patients with lung injury. Despite the proven benefits of hypercapnic acidosis, further safety studies including dose-effect, level-and-onset of anti-inflammatory effect, and safe applicability period need to be performed in various models of lung injury in animals and humans to further elucidate its protective role.

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