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Nicklasson M, Magnusson AB. Program for evaluating drug dissolution kinetics in preformulation. Pharm Res. 1985;2(6):262-6doi: 10.1023/A:1016333432224.
Nicklasson, M., & Magnusson, A. B. (1985). Program for evaluating drug dissolution kinetics in preformulation. Pharmaceutical research, 2(6), 262-6. https://doi.org/10.1023/A:1016333432224
Nicklasson, M, and Magnusson, A B. "Program for evaluating drug dissolution kinetics in preformulation." Pharmaceutical research vol. 2,6 (1985): 262-6. doi: https://doi.org/10.1023/A:1016333432224
Nicklasson M, Magnusson AB. Program for evaluating drug dissolution kinetics in preformulation. Pharm Res. 1985 Nov;2(6):262-6. doi: 10.1023/A:1016333432224. PMID: 24271121.
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Pharm Res. 1985 Nov;2(6):262-6. doi: 10.1023/A:1016333432224.

Program for evaluating drug dissolution kinetics in preformulation.

Pharmaceutical research

M Nicklasson, A B Magnusson

Affiliations

  1. Research and Development Laboratories, Pharmaceutics, Solid Systems, Astra Läkemedel AB, S-151 85, Södertälje, Sweden.

PMID: 24271121 DOI: 10.1023/A:1016333432224

Abstract

The in vitro dissolution kinetics of various drugs were studied at different experimental conditions using both a centrically rotating disc method and a modified excentrically rotating disc method. The combination of these two methods provides a preformulation program that includes many important pharmaceutical and biopharmaceutical parameters related to drug dissolution. The influence of the hydrodynamic conditions on the dissolution rate was demonstrated and the intrinsic dissolution tendency was obtained. Further, the acid dissociation constant, diffusion coefficient and enthalpy of dissolution can be calculated from data obtained from the rotating disc experiments. The relationship between dissolution rate and aqueous solubility of each drug tested is also considered.

References

  1. J Pharm Sci. 1964 Jun;53:679 - PubMed
  2. J Pharm Sci. 1965 Jul;54(7):1068 - PubMed
  3. Curr Ther Res Clin Exp. 1968 Jun;10(6):292-303 - PubMed
  4. J Pharm Sci. 1978 Aug;67(8):1059-66 - PubMed
  5. J Pharm Sci. 1975 Apr;64(4):610-4 - PubMed
  6. J Pharm Sci. 1985 Jan;74(1):16-20 - PubMed
  7. J Pharm Sci. 1968 Jun;57(6):959-65 - PubMed
  8. Lancet. 1973 Jun 2;1(7814):1215-7 - PubMed
  9. J Pharm Pharmacol. 1975 Aug;27(8):594-8 - PubMed
  10. J Pharm Sci. 1976 May;65(5):685-9 - PubMed
  11. J Pharm Sci. 1979 Mar;68(3):308-11 - PubMed
  12. Chem Pharm Bull (Tokyo). 1966 Apr;14(4):329-38 - PubMed
  13. J Pharm Sci. 1962 Aug;51:802-4 - PubMed
  14. J Pharm Sci. 1981 Jan;70(1):13-22 - PubMed

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