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Sharma S. Treatment of filariasis-diethylcarbamazine and its congeners. Pharm Res. 1986;3(2):75-80doi: 10.1023/A:1016385118265.
Sharma, S. (1986). Treatment of filariasis-diethylcarbamazine and its congeners. Pharmaceutical research, 3(2), 75-80. https://doi.org/10.1023/A:1016385118265
Sharma, S. "Treatment of filariasis-diethylcarbamazine and its congeners." Pharmaceutical research vol. 3,2 (1986): 75-80. doi: https://doi.org/10.1023/A:1016385118265
Sharma S. Treatment of filariasis-diethylcarbamazine and its congeners. Pharm Res. 1986 Apr;3(2):75-80. doi: 10.1023/A:1016385118265. PMID: 24271464.
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Pharm Res. 1986 Apr;3(2):75-80. doi: 10.1023/A:1016385118265.

Treatment of filariasis-diethylcarbamazine and its congeners.

Pharmaceutical research

S Sharma

Affiliations

  1. Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, 226001, India.

PMID: 24271464 DOI: 10.1023/A:1016385118265

Abstract

Structural modifications of diethylcarbamazine (DEC), a drug of choice for treating different forms of human filariasis, are analyzed in order to delineate structure-activity relationships among various piperazine and nonpiperazine DEC analogues. The acyclic congeners of DEC do not possess any activity, probably because of their ability to exist in many conformations. On the other hand, many substituted piperazines display microfilaricidal activity, although they are less potent than DEC. A few rigid analogues of DEC have been found to possess promising antifilarial activity. This survey highlights the therapeutic potential of DEC against filariasis and trends in the design of better filaricidic drugs with DEC as a prototype molecule.

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