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Davis SS, Stockwell AF, Taylor MJ, et al. The effect of density on the gastric emptying of single- and multiple-unit dosage forms. Pharm Res. 1986;3(4):208-13doi: 10.1023/A:1016334629169.
Davis, S. S., Stockwell, A. F., Taylor, M. J., Hardy, J. G., Whalley, D. R., Wilson, C. G., Bechgaard, H., & Christensen, F. N. (1986). The effect of density on the gastric emptying of single- and multiple-unit dosage forms. Pharmaceutical research, 3(4), 208-13. https://doi.org/10.1023/A:1016334629169
Davis, S S, et al. "The effect of density on the gastric emptying of single- and multiple-unit dosage forms." Pharmaceutical research vol. 3,4 (1986): 208-13. doi: https://doi.org/10.1023/A:1016334629169
Davis SS, Stockwell AF, Taylor MJ, Hardy JG, Whalley DR, Wilson CG, Bechgaard H, Christensen FN. The effect of density on the gastric emptying of single- and multiple-unit dosage forms. Pharm Res. 1986 Aug;3(4):208-13. doi: 10.1023/A:1016334629169. PMID: 24271583.
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Pharm Res. 1986 Aug;3(4):208-13. doi: 10.1023/A:1016334629169.

The effect of density on the gastric emptying of single- and multiple-unit dosage forms.

Pharmaceutical research

S S Davis, A F Stockwell, M J Taylor, J G Hardy, D R Whalley, C G Wilson, H Bechgaard, F N Christensen

Affiliations

  1. Department of Pharmacy, University of Nottingham, Nottingham, UK.

PMID: 24271583 DOI: 10.1023/A:1016334629169

Abstract

The gastric emptying of pellets and single units of different densities has been followed in healthy subjects using the technique of gamma scintigraphy. The gastric emptying of the light pellets was affected by their buoyancy in the upper part of the stomach. However, the mean gastric emptying rates of pellets and single units were not significantly affected by density. Floating or buoyant delivery systems may have little advantage over conventional systems. The presence of food in the stomach was found to be the major factor in determining the gastric emptying of single units.

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