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Chafetz L, Greenough RC, Frank J. Thermal decomposition of thonzonium bromide. Pharm Res. 1986;3(5):298-301doi: 10.1023/A:1016367503669.
Chafetz, L., Greenough, R. C., & Frank, J. (1986). Thermal decomposition of thonzonium bromide. Pharmaceutical research, 3(5), 298-301. https://doi.org/10.1023/A:1016367503669
Chafetz, L, et al. "Thermal decomposition of thonzonium bromide." Pharmaceutical research vol. 3,5 (1986): 298-301. doi: https://doi.org/10.1023/A:1016367503669
Chafetz L, Greenough RC, Frank J. Thermal decomposition of thonzonium bromide. Pharm Res. 1986 Oct;3(5):298-301. doi: 10.1023/A:1016367503669. PMID: 24271714.
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Pharm Res. 1986 Oct;3(5):298-301. doi: 10.1023/A:1016367503669.

Thermal decomposition of thonzonium bromide.

Pharmaceutical research

L Chafetz, R C Greenough, J Frank

Affiliations

  1. Product Development Laboratories, Warner-Lambert Research Institute, Morris Plains, New Jersey, 07950.

PMID: 24271714 DOI: 10.1023/A:1016367503669

Abstract

Thonzonium bromide, a quaternary ammonium compound used as a surface active agent in a phenylephrine nasal solution, gave a gas chromatographic peak which was proportional in height and area to its concentration. Quaternary ammonium salts are nonvolatile and polar, thus the peak was attributed to a thermal decomposition product. It was identified as hexadecyldimethylamine by spectroscopic analysis and comparison with an authentic sample. A second product was identified by mass spectroscopy as 2[(2-hexadecylmethylaminoethyl)(4-methoxybenzylamino)] pyrimidine, the desmethyl bromide product. These decomposition products were detected in stability samples of formulations.

References

  1. J Pharm Sci. 1984 Dec;73(12):1700-2 - PubMed

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