Display options
Cite
Mathews DC, Richards EM, Niciu MJ, et al. NEUROBIOLOGICAL ASPECTS OF SUICIDE AND SUICIDE ATTEMPTS IN BIPOLAR DISORDER. Transl Neurosci. 2013;4(2)doi: 10.2478/s13380-013-0120-7.
Mathews, D. C., Richards, E. M., Niciu, M. J., Ionescu, D. F., Rasimas, J. J., & Zarate, C. A. (2013). NEUROBIOLOGICAL ASPECTS OF SUICIDE AND SUICIDE ATTEMPTS IN BIPOLAR DISORDER. Translational neuroscience, 4(2), . https://doi.org/10.2478/s13380-013-0120-7
Mathews, Daniel C, et al. "NEUROBIOLOGICAL ASPECTS OF SUICIDE AND SUICIDE ATTEMPTS IN BIPOLAR DISORDER." Translational neuroscience vol. 4,2 (2013). doi: https://doi.org/10.2478/s13380-013-0120-7
Mathews DC, Richards EM, Niciu MJ, Ionescu DF, Rasimas JJ, Zarate CA. NEUROBIOLOGICAL ASPECTS OF SUICIDE AND SUICIDE ATTEMPTS IN BIPOLAR DISORDER. Transl Neurosci. 2013 Jun;4(2). doi: 10.2478/s13380-013-0120-7. PMID: 24294519; PMCID: PMC3840723.
Copy Download .nbib Format: NLM
Share it on

Transl Neurosci. 2013 Jun;4(2). doi: 10.2478/s13380-013-0120-7.

NEUROBIOLOGICAL ASPECTS OF SUICIDE AND SUICIDE ATTEMPTS IN BIPOLAR DISORDER.

Translational neuroscience

Daniel C Mathews, Erica M Richards, Mark J Niciu, Dawn F Ionescu, Joseph J Rasimas, Carlos A Zarate

Affiliations

  1. Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

PMID: 24294519 PMCID: PMC3840723 DOI: 10.2478/s13380-013-0120-7

Abstract

Suicide and bipolar disorder (BD) are challenging, complex, and intertwined areas of study in contemporary psychiatry. Indeed, BD is associated with the highest lifetime risk for suicide attempt and completion of all the psychiatric conditions. Given that several clinical risk factors for both suicide and BD have been well noted in the literature, exploring the neurobiological aspects of suicide in BD may provide insights into both preventive measures and future novel treatments. This review synthesizes findings regarding the neurobiological aspects of suicide and, when applicable, their link to BD. Neurochemical findings, genes/epigenetics, and potential molecular targets for current or future treatments are discussed. The role of endophenotypes and related proximal and distal risk factors underlying suicidal behavior are also explored. Lastly, we discuss the manner in which preclinical work on aggression and impulsivity may provide additional insights for the future development of novel treatments.

Keywords: Bipolar disorder; Depression; Glutamate; Neurobiology; Suicidal behavior; Suicide; Treatment

References

  1. J Affect Disord. 2012 Feb;136(3):350-8 - PubMed
  2. Arch Gen Psychiatry. 1990 Nov;47(11):1038-47 - PubMed
  3. Nat Neurosci. 2009 Mar;12(3):342-8 - PubMed
  4. J Clin Psychiatry. 2011 Aug;72(8):1027-33 - PubMed
  5. Neuropsychopharmacology. 2012 Feb;37(3):697-706 - PubMed
  6. Am J Psychiatry. 2002 Mar;159(3):419-29 - PubMed
  7. Biol Psychiatry. 2009 Nov 1;66(9):812-3 - PubMed
  8. Biol Psychiatry. 1997 Jan 15;41(2):162-71 - PubMed
  9. Neuropsychobiology. 2010;62(1):50-60 - PubMed
  10. Am J Psychiatry. 2004 Nov;161(11):2123-6 - PubMed
  11. Biol Psychiatry. 1996 Jan 15;39(2):112-20 - PubMed
  12. Biol Psychiatry. 2006 Apr 1;59(7):594-602 - PubMed
  13. Neuropsychobiology. 2010;62(1):43-9 - PubMed
  14. Pharmacopsychiatry. 1999 Jan;32(1):1-4 - PubMed
  15. J Affect Disord. 2009 Jul;116(1-2):117-20 - PubMed
  16. Arch Gen Psychiatry. 1988 Jun;45(6):577-9 - PubMed
  17. Science. 2001 Nov 9;294(5545):1354-7 - PubMed
  18. Am J Psychiatry. 1989 Jun;146(6):730-6 - PubMed
  19. Am J Psychiatry. 2002 Jan;159(1):66-73 - PubMed
  20. Am J Psychiatry. 2011 Oct;168(10):1009-11 - PubMed
  21. Am J Psychiatry. 1996 Aug;153(8):1009-14 - PubMed
  22. Am J Psychiatry. 1976 Dec;133(12):1409-13 - PubMed
  23. Suicide Life Threat Behav. 1994 Spring;24(1):1-9 - PubMed
  24. Brain Res. 1995 Aug 7;688(1-2):121-33 - PubMed
  25. Eur Psychiatry. 2010 Jun;25(5):268-71 - PubMed
  26. Brain Res. 1996 Jun 3;723(1-2):37-45 - PubMed
  27. Int J Neuropsychopharmacol. 2006 Aug;9(4):465-74 - PubMed
  28. Biol Psychiatry. 1992 Jul 1;32(1):57-71 - PubMed
  29. J Neurochem. 2009 Dec;111(6):1357-68 - PubMed
  30. Arch Gen Psychiatry. 2006 Aug;63(8):856-64 - PubMed
  31. Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 5;147B(1):42-8 - PubMed
  32. Suicide Life Threat Behav. 1986 Summer;16(2):286-300 - PubMed
  33. Arch Gen Psychiatry. 2010 Aug;67(8):793-802 - PubMed
  34. J Neural Transm. 1987;70(3-4):377-81 - PubMed
  35. Psychiatry Res. 1979 Oct;1(2):131-9 - PubMed
  36. Am J Psychiatry. 2011 Oct;168(10):1050-6 - PubMed
  37. Lancet. 1983 Jan 29;1(8318):214-6 - PubMed
  38. Arch Gen Psychiatry. 2004 Jul;61(7):685-93 - PubMed
  39. Am J Psychiatry. 2012 Nov;169(11):1150-6 - PubMed
  40. Lancet. 1992 Oct 17;340(8825):940-1 - PubMed
  41. PLoS One. 2012;7(3):e31720 - PubMed
  42. Int J Neuropsychopharmacol. 2012 Sep;15(8):1161-6 - PubMed
  43. J Psychiatr Res. 2011 Nov;45(11):1489-96 - PubMed
  44. Mol Psychiatry. 2009 Sep;14(9):830-2 - PubMed
  45. JAMA. 2003 Sep 17;290(11):1467-73 - PubMed
  46. Psychopharmacology (Berl). 2012 Jan;219(2):421-32 - PubMed
  47. Mol Psychiatry. 2006 Apr;11(4):336-51 - PubMed
  48. Epidemiol Psichiatr Soc. 2009 Jul-Sep;18(3):179-83 - PubMed
  49. Biol Psychiatry. 1997 Feb 1;41(3):264-72 - PubMed
  50. Psychiatr Clin North Am. 2008 Jun;31(2):179-203 - PubMed
  51. J Clin Psychiatry. 2012 Jun;73(6):778-82 - PubMed
  52. Acta Psychiatr Scand. 2008 Dec;118(6):469-79 - PubMed
  53. J Clin Psychiatry. 2008 Aug;69(8):1228-1236 - PubMed
  54. J Clin Psychiatry. 2000;61 Suppl 9:47-51 - PubMed
  55. Synapse. 1997 Nov;27(3):168-76 - PubMed
  56. Neuropsychopharmacology. 2013 Apr;38(5):743-52 - PubMed
  57. Mol Psychiatry. 2001 Sep;6(5):540-6 - PubMed
  58. Ann N Y Acad Sci. 2007 Jan;1096:157-69 - PubMed
  59. Am J Psychiatry. 2005 Feb;162(2):304-10 - PubMed
  60. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Feb 1;33(1):109-12 - PubMed
  61. Neuropsychopharmacology. 1995 Aug;13(1):53-64 - PubMed
  62. Int J Neuropsychopharmacol. 2009 Nov;12(10):1327-35 - PubMed
  63. Am J Psychiatry. 2001 May;158(5):748-53 - PubMed
  64. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jun 1;35(4):842-7 - PubMed
  65. Arch Gen Psychiatry. 1992 Jun;49(6):447-50 - PubMed
  66. Pharmacogenomics. 2010 Oct;11(10):1439-65 - PubMed
  67. Neuropsychopharmacology. 2005 Aug;30(8):1548-56 - PubMed
  68. Am J Psychiatry. 1995 Mar;152(3):419-23 - PubMed
  69. Br J Psychiatry. 1997 Mar;170:205-28 - PubMed
  70. J Affect Disord. 2004 Dec;83(2-3):103-8 - PubMed
  71. BMJ. 1990 Aug 11;301(6747):309-14 - PubMed
  72. Am J Psychiatry. 1986 Dec;143(12):1539-45 - PubMed
  73. Arch Gen Psychiatry. 2003 Aug;60(8):804-15 - PubMed
  74. Brain Res. 1993 Jun 18;614(1-2):37-44 - PubMed
  75. Braz J Psychiatry. 2009 Sep;31(3):271-80 - PubMed
  76. Arch Gen Psychiatry. 2010 Mar;67(3):258-67 - PubMed
  77. Psychiatry Res. 2007 Mar 30;150(2):187-91 - PubMed
  78. J Affect Disord. 2009 Feb;113(1-2):45-55 - PubMed
  79. Psychol Med. 2013 Mar;43(3):539-51 - PubMed
  80. J Clin Psychiatry. 1996 Oct;57(10):470-84 - PubMed
  81. J Clin Psychiatry. 2008 Aug;69(8):1237-45 - PubMed
  82. Biol Psychiatry. 2011 Jan 15;69(2):127-33 - PubMed
  83. Bipolar Disord. 2001 Dec;3(6):335-49 - PubMed
  84. Arch Gen Psychiatry. 2003 Mar;60(3):273-82 - PubMed
  85. Mol Psychiatry. 2003 Jul;8(7):646-53 - PubMed
  86. Eur Neuropsychopharmacol. 2000 Jul;10(4):283-8 - PubMed
  87. Psychiatry Res. 1992 Aug;43(2):137-46 - PubMed
  88. Biol Psychiatry. 1986 Jul;21(8-9):756-67 - PubMed
  89. Arch Gen Psychiatry. 1996 Apr;53(4):339-48 - PubMed
  90. Arch Gen Psychiatry. 1992 Jun;49(6):442-6 - PubMed
  91. Am J Psychiatry. 2001 May;158(5):735-41 - PubMed
  92. Arch Gen Psychiatry. 1981 Dec;38(12):1322-6 - PubMed
  93. Psychiatr Serv. 1998 Aug;49(8):1029-33 - PubMed
  94. Expert Rev Neurother. 2012 Mar;12(3):257-9 - PubMed
  95. Neuroendocrinology. 1992 Oct;56(4):491-501 - PubMed
  96. Psychiatry Res. 1980 Oct;3(2):211-23 - PubMed
  97. Neuropsychopharmacology. 2004 Aug;29(8):1512-21 - PubMed
  98. Bipolar Disord. 2006 Oct;8(5 Pt 2):625-39 - PubMed
  99. Mol Psychiatry. 2005 Mar;10(3):275-87 - PubMed
  100. Biol Psychiatry. 1992 Nov 1;32(9):812-6 - PubMed
  101. J Clin Psychopharmacol. 2001 Dec;21(6):621-2 - PubMed
  102. Biol Psychiatry. 1994 Sep 15;36(6):374-80 - PubMed
  103. Am J Med Genet. 2002 May 8;114(4):391-406 - PubMed
  104. Arch Gen Psychiatry. 2006 Jan;63(1):35-48 - PubMed
  105. Biol Psychiatry. 2006 Jul 15;60(2):163-76 - PubMed
  106. Brain Res. 2005 Apr 11;1041(1):19-28 - PubMed
  107. Arch Gen Psychiatry. 1976 Oct;33(10):1193-7 - PubMed
  108. Biol Psychiatry. 1994 Jun 15;35(12):957-9 - PubMed
  109. Arch Suicide Res. 2008;12(2):93-110 - PubMed
  110. Neurobiol Dis. 2012 Jan;45(1):14-22 - PubMed
  111. Asian J Psychiatr. 2011 Mar 1;4(1):2-13 - PubMed
  112. Biol Psychiatry. 2008 Oct 15;64(8):645-52 - PubMed
  113. Trends Neurosci. 2012 Jan;35(1):14-23 - PubMed
  114. Mol Psychiatry. 2003 Mar;8(3):324-32 - PubMed
  115. Arch Gen Psychiatry. 2003 Jan;60(1):82-91 - PubMed
  116. Biol Psychiatry. 2009 Sep 1;66(5):522-6 - PubMed
  117. Am J Psychiatry. 1999 Feb;156(2):181-9 - PubMed
  118. Neurosci Biobehav Rev. 2007;31(6):932-62 - PubMed
  119. Genes Brain Behav. 2006 Mar;5(2):113-9 - PubMed
  120. Biol Psychiatry. 2006 Jul 15;60(2):93-105 - PubMed
  121. J Clin Psychopharmacol. 2012 Oct;32(5):735-6 - PubMed
  122. Bipolar Disord. 2006 Oct;8(5 Pt 2):551-7 - PubMed
  123. Science. 2012 Oct 5;338(6103):68-72 - PubMed
  124. Arch Gen Psychiatry. 1986 Oct;43(10):954-9 - PubMed
  125. J Neural Transm (Vienna). 2001;108(7):869-78 - PubMed
  126. Neuropsychopharmacology. 1996 Dec;15(6):576-86 - PubMed
  127. BMC Genomics. 2007 Nov 12;8:413 - PubMed
  128. Int J Neuropsychopharmacol. 2007 Oct;10(5):621-9 - PubMed
  129. J Affect Disord. 2009 Feb;113(1-2):21-9 - PubMed
  130. Actas Esp Psiquiatr. 2010 Jul-Aug;38(4):223-8 - PubMed
  131. Neuropsychobiology. 2011;63(2):125-30 - PubMed
  132. Brain Res. 1995 Mar 27;675(1-2):157-64 - PubMed
  133. Neuropsychopharmacology. 2004 Mar;29(3):619-25 - PubMed
  134. Neuropsychopharmacol Hung. 2012 Dec;14(4):231-8 - PubMed
  135. Arch Gen Psychiatry. 2009 Jan;66(1):22-32 - PubMed
  136. Br Med J. 1968 Aug 3;3(5613):285-7 - PubMed
  137. Neuropsychopharmacology. 2002 Oct;27(4):499-517 - PubMed
  138. Biol Psychiatry. 1999 Aug 15;46(4):473-83 - PubMed
  139. Neurology. 1986 May;36(5):641-6 - PubMed
  140. Nat Rev Neurosci. 2003 Oct;4(10):819-28 - PubMed
  141. J Neurochem. 2011 Jul;118(1):126-39 - PubMed
  142. Arch Gen Psychiatry. 1997 Mar;54(3):214-22 - PubMed
  143. Wien Klin Wochenschr. 2007;119(15-16):463-75 - PubMed
  144. J Clin Psychiatry. 2010 Dec;71(12):1605-11 - PubMed
  145. Am J Psychiatry. 1998 Apr;155(4):543-7 - PubMed
  146. Brain Res. 1990 Oct 22;530(2):312-6 - PubMed
  147. Epidemiology. 2001 Mar;12(2):168-72 - PubMed
  148. Annu Rev Pharmacol Toxicol. 2009;49:175-98 - PubMed
  149. Suicide Life Threat Behav. 1989 Spring;19(1):30-42 - PubMed
  150. Psychiatry Res. 1986 Oct;19(2):105-12 - PubMed
  151. Acta Psychiatr Scand. 2008 Mar;117(3):198-206 - PubMed
  152. Biol Psychiatry. 2010 Mar 1;67(5):432-8 - PubMed
  153. Future Neurol. 2010 Sep;5(5):701-720 - PubMed
  154. Depress Anxiety. 2011 Apr;28(4):303-9 - PubMed
  155. Pharmacol Rev. 1991 Dec;43(4):425-73 - PubMed
  156. Dev Psychobiol. 2010 Nov;52(7):671-90 - PubMed
  157. Curr Psychiatry Rep. 2009 Dec;11(6):481-7 - PubMed
  158. Am J Psychiatry. 1999 Dec;156(12):1895-901 - PubMed
  159. Am J Psychiatry. 2003 Apr;160(4):636-45 - PubMed
  160. J Psychiatr Res. 2012 Oct;46(10):1267-71 - PubMed
  161. Psychoneuroendocrinology. 2008 Jul;33(6):693-710 - PubMed
  162. Psychopharmacol Bull. 1986;22(3):656-60 - PubMed
  163. Biol Psychiatry. 1997 Jan 15;41(2):196-200 - PubMed
  164. Brain Res. 1994 Jan 7;633(1-2):297-304 - PubMed
  165. Biol Psychiatry. 2012 Jun 1;71(11):939-46 - PubMed
  166. Mol Psychiatry. 2010 Aug;15(8):868-76 - PubMed
  167. Psychiatr Clin North Am. 2008 Jun;31(2):247-69 - PubMed
  168. N Engl J Med. 1987 Nov 12;317(20):1237-45 - PubMed
  169. J Neurochem. 1998 Mar;70(3):1114-23 - PubMed
  170. PLoS One. 2009 Aug 11;4(8):e6585 - PubMed
  171. Arch Gen Psychiatry. 2006 Oct;63(10):1121-9 - PubMed
  172. Arch Gen Psychiatry. 1965 Sep;13:232-9 - PubMed
  173. Arch Suicide Res. 2005;9(1):27-34 - PubMed
  174. Int J Neuropsychopharmacol. 2011 Sep;14(8):1127-31 - PubMed
  175. Transl Psychiatry. 2011;1: - PubMed
  176. Bipolar Disord. 2006 Oct;8(5 Pt 2):543-50 - PubMed
  177. Bipolar Disord. 2011 Jun;13(4):377-86 - PubMed
  178. Neurosci Lett. 1997 Jun 6;228(2):111-4 - PubMed
  179. Biol Psychiatry. 2009 Aug 1;66(3):287-92 - PubMed
  180. Bipolar Disord. 2012 Mar;14(2):206-10 - PubMed
  181. J Psychiatr Res. 2008 Jan;42(2):151-7 - PubMed
  182. J Abnorm Psychol. 2010 Aug;119(3):616-22 - PubMed
  183. PLoS One. 2012;7(1):e29297 - PubMed
  184. Am J Psychiatry. 1996 Aug;153(8):974-84 - PubMed
  185. World J Biol Psychiatry. 2011 Aug;12(5):319-39 - PubMed
  186. Am J Psychiatry. 1981 Aug;138(8):1120-1 - PubMed
  187. Am J Psychiatry. 2010 Dec;167(12):1499-507 - PubMed
  188. Am J Psychiatry. 2005 Oct;162(10):1805-19 - PubMed

Publication Types

Grant support