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Bhattacharya SK. Prostaglandins and central serotonergic activity in the rat. Pharm Res. 1985;2(5):195-8doi: 10.1023/A:1016300424955.
Bhattacharya, S. K. (1985). Prostaglandins and central serotonergic activity in the rat. Pharmaceutical research, 2(5), 195-8. https://doi.org/10.1023/A:1016300424955
Bhattacharya, S K. "Prostaglandins and central serotonergic activity in the rat." Pharmaceutical research vol. 2,5 (1985): 195-8. doi: https://doi.org/10.1023/A:1016300424955
Bhattacharya SK. Prostaglandins and central serotonergic activity in the rat. Pharm Res. 1985 Sep;2(5):195-8. doi: 10.1023/A:1016300424955. PMID: 24272834.
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Pharm Res. 1985 Sep;2(5):195-8. doi: 10.1023/A:1016300424955.

Prostaglandins and central serotonergic activity in the rat.

Pharmaceutical research

S K Bhattacharya

Affiliations

  1. Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, India.

PMID: 24272834 DOI: 10.1023/A:1016300424955

Abstract

Pharmacological and biochemical studies indicate that prostaglandins (PGs) exert a modulatory influence on rat brain serotonergic activity. With several experimental approaches, it has been shown that PGEs and PGD2 facilitate central serotonergic activity in rats. On the contrary, PGF2α not only inhibits rat brain serotonergic activity but also antagonizes the facilitatory effect of the other PGs. The studies support the proposed neuromodulatory role for PGs in central synaptic transmission.

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